A Molecular Mechanism for Turning Off IRE1α Signaling during Endoplasmic Reticulum Stress

Misfolded proteins in the endoplasmic reticulum (ER) activate IRE1α endoribonuclease in mammalian cells, which mediates XBP1 mRNA splicing to produce an active transcription factor. This promotes the expression of specific genes to alleviate ER stress, thereby attenuating IRE1α. Although sustained a...

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Detalles Bibliográficos
Autores principales: Li, Xia, Sun, Sha, Appathurai, Suhila, Sundaram, Arunkumar, Plumb, Rachel, Mariappan, Malaiyalam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809255/
https://www.ncbi.nlm.nih.gov/pubmed/33378667
http://dx.doi.org/10.1016/j.celrep.2020.108563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809255/
https://www.ncbi.nlm.nih.gov/pubmed/33378667
http://dx.doi.org/10.1016/j.celrep.2020.108563

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