Cargando…

A Molecular Mechanism for Turning Off IRE1α Signaling during Endoplasmic Reticulum Stress

Misfolded proteins in the endoplasmic reticulum (ER) activate IRE1α endoribonuclease in mammalian cells, which mediates XBP1 mRNA splicing to produce an active transcription factor. This promotes the expression of specific genes to alleviate ER stress, thereby attenuating IRE1α. Although sustained a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xia, Sun, Sha, Appathurai, Suhila, Sundaram, Arunkumar, Plumb, Rachel, Mariappan, Malaiyalam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809255/ https://www.ncbi.nlm.nih.gov/pubmed/33378667 http://dx.doi.org/10.1016/j.celrep.2020.108563

Ejemplares similares

Dynamic changes in complexes of IRE1α, PERK, and ATF6α during endoplasmic reticulum stress
por: Sundaram, Arunkumar, et al.
Publicado: (2018)

The Sec61 translocon limits IRE1α signaling during the unfolded protein response
por: Sundaram, Arunkumar, et al.
Publicado: (2017)

A functional link between the co-translational protein translocation pathway and the UPR
por: Plumb, Rachel, et al.
Publicado: (2015)

Signal sequences encode information for protein folding in the endoplasmic reticulum
por: Sun, Sha, et al.
Publicado: (2022)

IRE1α is an endogenous substrate of endoplasmic reticulum-associated degradation
por: Sun, Shengyi, et al.
Publicado: (2015)

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress
por: Grey, Michael J., et al.
Publicado: (2020)

IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases
por: Junjappa, Raghu Patil, et al.
Publicado: (2018)

Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α
por: Le Thomas, Adrien, et al.
Publicado: (2021)

Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity
por: Rubio, Claudia, et al.
Publicado: (2011)

Inositol Requiring Enzyme (IRE), a multiplayer in sensing endoplasmic reticulum stress
por: Zhou, Zhixin, et al.
Publicado: (2022)

Endoplasmic Reticulum Stress Sensor IRE1α Enhances IL-23 Expression by Human Dendritic Cells
por: Márquez, Saioa, et al.
Publicado: (2017)

Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular Physiology, Calcium, ROS Signaling, and Metaflammation
por: Riaz, Thoufiqul Alam, et al.
Publicado: (2020)

Induction of the Endoplasmic-Reticulum-Stress Response: MicroRNA-34a Targeting of the IRE1α-Branch
por: Krammes, Lena, et al.
Publicado: (2020)

IRE1α and IGF signaling predict resistance to an endoplasmic reticulum stress-inducing drug in glioblastoma cells
por: Rodvold, Jeffrey J., et al.
Publicado: (2020)

Melatonin Improves Endoplasmic Reticulum Stress-Mediated IRE1α Pathway in Zücker Diabetic Fatty Rat
por: Aouichat, Samira, et al.
Publicado: (2021)

Quercetin Affects Hsp70/IRE1α Mediated Protection from Death Induced by Endoplasmic Reticulum Stress
por: Storniolo, Antonello, et al.
Publicado: (2015)

Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties
por: Givord, Charlotte, et al.
Publicado: (2018)

Hyperoxia induces endoplasmic reticulum stress-associated apoptosis via the IRE1α pathway in rats with bronchopulmonary dysplasia
por: Tong, Xin, et al.
Publicado: (2021)

Apocynin protects endothelial cells from endoplasmic reticulum stress-induced apoptosis via IRE1α engagement
por: Wu, Jie, et al.
Publicado: (2018)

Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers
por: Belyy, Vladislav, et al.
Publicado: (2022)

The endoplasmic reticulum stress sensor IRE1α modulates macrophage metabolic function during Brucella abortus infection
por: Guimarães, Erika S., et al.
Publicado: (2023)

IRES-Dependent Translational Control during Virus-Induced Endoplasmic Reticulum Stress and Apoptosis
por: Hanson, Paul J., et al.
Publicado: (2012)

Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling
por: Cohen, Nir, et al.
Publicado: (2017)

A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability
por: Liu, Jiang, et al.
Publicado: (2017)

Mesenchymal Stem Cells Inhibit Epithelial-to-Mesenchymal Transition by Modulating the IRE1α Branch of the Endoplasmic Reticulum Stress Response
por: Luo, Ruixi, et al.
Publicado: (2023)

The natural product salicin alleviates osteoarthritis progression by binding to IRE1α and inhibiting endoplasmic reticulum stress through the IRE1α-IκBα-p65 signaling pathway
por: Zhu, Zhenglin, et al.
Publicado: (2022)

A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1
por: Kimata, Yukio, et al.
Publicado: (2004)

Transdifferentiation mediated tumor suppression by the endoplasmic reticulum stress sensor IRE-1 in C. elegans
por: Levi-Ferber, Mor, et al.
Publicado: (2015)

Probing natural variation of IRE1 expression and endoplasmic reticulum stress responses in Arabidopsis accessions
por: Afrin, Taiaba, et al.
Publicado: (2020)

Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1α/XBP1 pathway
por: Namba, Takushi, et al.
Publicado: (2015)

Endoplasmic reticulum stress enhances fibrosis through IRE1α‐mediated degradation of miR‐150 and XBP‐1 splicing
por: Heindryckx, Femke, et al.
Publicado: (2016)

IRE1α siRNA relieves endoplasmic reticulum stress-induced apoptosis and alleviates diabetic peripheral neuropathy in vivo and in vitro
por: Yao, Weijie, et al.
Publicado: (2018)

Intense endoplasmic reticulum stress (ERS) / IRE1α enhanced Oxaliplatin efficacy by decreased ABCC10 in colorectal cancer cells
por: Liu, Xiaohui, et al.
Publicado: (2022)

CaMKII orchestrates endoplasmic reticulum stress and apoptosis in doxorubicin‐induced cardiotoxicity by regulating the IRE1α/XBP1s pathway
por: Kong, Lingheng, et al.
Publicado: (2022)

Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
por: Promlek, Thanyarat, et al.
Publicado: (2011)

In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress
por: Kopp, Megan C, et al.
Publicado: (2018)

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress
por: Shemorry, Anna, et al.
Publicado: (2019)

The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1
por: Acosta-Alvear, Diego, et al.
Publicado: (2018)

The ADP-binding kinase region of Ire1 directly contributes to its responsiveness to endoplasmic reticulum stress
por: Le, Quynh Giang, et al.
Publicado: (2021)

RNAi Screen of Endoplasmic Reticulum–Associated Host Factors Reveals a Role for IRE1α in Supporting Brucella Replication
por: Qin, Qing-Ming, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_m0psk05pe62lh48l80hjggmt4a