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Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation
Sleep deprivation is a form of stress that provokes both inflammatory responses and neuropsychiatric disorders. Because persistent inflammation is implicated as a physiological process in anxiety disorders, we investigated the contributions of NLRP3 inflammasome signaling to anxiety and anxiolytic p...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809257/ https://www.ncbi.nlm.nih.gov/pubmed/33446652 http://dx.doi.org/10.1038/s41398-020-01189-3 |
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author | Smith, Chad Trageser, Kyle J. Wu, Henry Herman, Francis J. Iqbal, Umar Haris Sebastian-Valverde, Maria Frolinger, Tal Zeng, Emma Pasinetti, Giulio Maria |
author_facet | Smith, Chad Trageser, Kyle J. Wu, Henry Herman, Francis J. Iqbal, Umar Haris Sebastian-Valverde, Maria Frolinger, Tal Zeng, Emma Pasinetti, Giulio Maria |
author_sort | Smith, Chad |
collection | PubMed |
description | Sleep deprivation is a form of stress that provokes both inflammatory responses and neuropsychiatric disorders. Because persistent inflammation is implicated as a physiological process in anxiety disorders, we investigated the contributions of NLRP3 inflammasome signaling to anxiety and anxiolytic properties of flavanol diets in a model of chronic sleep deprivation. The results show a flavanol-rich dietary preparation (FDP) exhibits anxiolytic properties by attenuating markers of neuroimmune activation, which included IL-1β upregulation, NLRP3 signaling, and microglia activation in the cortex and hippocampus of sleep-deprived mice. Production of IL-1β and NLRP3 were critical for both anxiety phenotypes and microglia activation. Individual FDP metabolites potently inhibited IL-1β production from microglia following stimulation with NLRP3-specific agonists, supporting anxiolytic properties of FDP observed in models of sleep deprivation involve inhibition of the NLRP3 inflammasome. The study further showed sleep deprivation alters the expression of the circadian gene Bmal1, which critically regulated NLRP3 expression and IL-1β production. |
format | Online Article Text |
id | pubmed-7809257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78092572021-01-21 Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation Smith, Chad Trageser, Kyle J. Wu, Henry Herman, Francis J. Iqbal, Umar Haris Sebastian-Valverde, Maria Frolinger, Tal Zeng, Emma Pasinetti, Giulio Maria Transl Psychiatry Article Sleep deprivation is a form of stress that provokes both inflammatory responses and neuropsychiatric disorders. Because persistent inflammation is implicated as a physiological process in anxiety disorders, we investigated the contributions of NLRP3 inflammasome signaling to anxiety and anxiolytic properties of flavanol diets in a model of chronic sleep deprivation. The results show a flavanol-rich dietary preparation (FDP) exhibits anxiolytic properties by attenuating markers of neuroimmune activation, which included IL-1β upregulation, NLRP3 signaling, and microglia activation in the cortex and hippocampus of sleep-deprived mice. Production of IL-1β and NLRP3 were critical for both anxiety phenotypes and microglia activation. Individual FDP metabolites potently inhibited IL-1β production from microglia following stimulation with NLRP3-specific agonists, supporting anxiolytic properties of FDP observed in models of sleep deprivation involve inhibition of the NLRP3 inflammasome. The study further showed sleep deprivation alters the expression of the circadian gene Bmal1, which critically regulated NLRP3 expression and IL-1β production. Nature Publishing Group UK 2021-01-14 /pmc/articles/PMC7809257/ /pubmed/33446652 http://dx.doi.org/10.1038/s41398-020-01189-3 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Smith, Chad Trageser, Kyle J. Wu, Henry Herman, Francis J. Iqbal, Umar Haris Sebastian-Valverde, Maria Frolinger, Tal Zeng, Emma Pasinetti, Giulio Maria Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation |
title | Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation |
title_full | Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation |
title_fullStr | Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation |
title_full_unstemmed | Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation |
title_short | Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation |
title_sort | anxiolytic effects of nlrp3 inflammasome inhibition in a model of chronic sleep deprivation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809257/ https://www.ncbi.nlm.nih.gov/pubmed/33446652 http://dx.doi.org/10.1038/s41398-020-01189-3 |
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