PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells

To date, there is no representative in vitro model for liver sinusoidal endothelial cells (LSECs), as primary LSECs dedifferentiate very fast in culture and no combination of cytokines or growth factors can induce an LSEC fate in (pluripotent stem cell (PSC)-derived) endothelial cells (ECs). Further...

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Detalles Bibliográficos
Autores principales: De Smedt, Jonathan, van Os, Elise Anne, Talon, Irene, Ghosh, Sreya, Toprakhisar, Burak, Furtado Madeiro Da Costa, Rodrigo, Zaunz, Samantha, Vazquez, Marta Aguirre, Boon, Ruben, Baatsen, Pieter, Smout, Ayla, Verhulst, Stefaan, van Grunsven, Leo A., Verfaillie, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809369/
https://www.ncbi.nlm.nih.gov/pubmed/33446637
http://dx.doi.org/10.1038/s41419-020-03356-2

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