Cargando…

Adaptive resistance to PI3Kα-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells

Phosphoinositide-3 kinase alpha-specific inhibitors (PI3Kαi) displayed promising potential for the treatment of esophageal squamous cell carcinoma (ESCC) with frequent activation in PI3K signaling. However, acquired resistance is likely to develop and limit the efficacy of PI3Kαi like other targeted...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yu-xiang, Zhang, Xu, Ma, Qing-yang, Hu, Lan-dian, Zhang, Xi, Wang, Yi, Xu, Lan, Yang, Chun-hao, Tan, Cun, Kong, Xiang-yin, Ding, Jian, Meng, Ling-hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809409/ https://www.ncbi.nlm.nih.gov/pubmed/33446653 http://dx.doi.org/10.1038/s41419-020-03370-4

Ejemplares similares

PI3Kα inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8(+)T cells and promoting fatty acid metabolism
por: Sun, Pu, et al.
Publicado: (2021)

First-in-human phase Ia study of the PI3Kα inhibitor CYH33 in patients with solid tumors
por: Wei, Xiao-Li, et al.
Publicado: (2022)

New Thio-Compounds and Monoterpenes With Anti-inflammatory Activities From the Fungus Aspergillus sp. CYH26
por: Pan, Guojun, et al.
Publicado: (2021)

Gambogic acid affects ESCC progression through regulation of PI3K/AKT/mTOR signal pathway
por: Yu, Jiarui, et al.
Publicado: (2020)

Fibroblasts in metastatic lymph nodes confer cisplatin resistance to ESCC tumor cells via PI16
por: Liang, Lily, et al.
Publicado: (2023)

MEX3A is upregulated in esophageal squamous cell carcinoma (ESCC) and promotes development and progression of ESCC through targeting CDK6
por: Wei, Lei, et al.
Publicado: (2020)

Prognosis and Progression of ESCC Patients with Perineural Invasion
por: Xu, Guanghui, et al.
Publicado: (2017)

Novel ESCC-related gene ZNF750 as potential Prognostic biomarker and inhibits Epithelial-Mesenchymal Transition through directly depressing SNAI1 promoter in ESCC
por: Kong, Pengzhou, et al.
Publicado: (2020)

Irradiation-induced exosomal HMGB1 to confer radioresistance via the PI3K/AKT/FOXO3A signaling pathway in ESCC
por: Du, Xingyu, et al.
Publicado: (2022)

Polymorphisms in the ERCC5 Gene and Risk of Esophageal Squamous Cell Carcinoma (ESCC) in Eastern Chinese Populations
por: Zhu, Mei-Ling, et al.
Publicado: (2012)

Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kα inhibition in breast cancer
por: Liu, Xue-Ling, et al.
Publicado: (2019)

High TSTA3 Expression as a Candidate Biomarker for Poor Prognosis of Patients With ESCC
por: Yang, Jie, et al.
Publicado: (2018)

Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors
por: Zhang, Xu, et al.
Publicado: (2023)

ATF3 suppresses ESCC via downregulation of ID1
por: Li, Jian, et al.
Publicado: (2016)

Novel preoperative nutritional assessment tool and prognostic model for ESCC patients
por: Xu, Jinming, et al.
Publicado: (2019)

UBE2C is overexpressed in ESCC tissues and its abrogation attenuates the malignant phenotype of ESCC cell lines
por: Palumbo, Antonio, et al.
Publicado: (2016)

circ_NRIP1 is oncogenic in malignant development of esophageal squamous cell carcinoma (ESCC) via miR-595/SEMA4D axis and PI3K/AKT pathway
por: Zhou, Shifan, et al.
Publicado: (2021)

Characterization of super‐enhancer‐associated functional lncRNAs acting as ceRNAs in ESCC
por: Wang, Qiu‐Yu, et al.
Publicado: (2020)

DEPDC1B collaborates with GABRD to regulate ESCC progression
por: Yuan, Yunfeng, et al.
Publicado: (2022)

Fusobacterium nucleatum induces MDSCs enrichment via activation the NLRP3 inflammosome in ESCC cells, leading to cisplatin resistance
por: Liang, Mengxia, et al.
Publicado: (2022)

The Effects of Interleukin-33 (IL-33) on Osteosarcoma Cell Viability, Apoptosis, and Epithelial-Mesenchymal Transition are Mediated Through the PI3K/AKT Pathway
por: Wang, Shenyu, et al.
Publicado: (2020)

ARHGAP10 inhibits the epithelial–mesenchymal transition of non-small cell lung cancer by inactivating PI3K/Akt/GSK3β signaling pathway
por: Lin, Lan-Lan, et al.
Publicado: (2021)

Elevated Maspin Expression Is Associated with Better Overall Survival in Esophageal Squamous Cell Carcinoma (ESCC)
por: Wang, Yang, et al.
Publicado: (2013)

HMGB1 overexpression promotes a malignant phenotype and radioresistance in ESCC
por: Dong, Jing, et al.
Publicado: (2022)

The interaction of lncRNA EZR-AS1 with SMYD3 maintains overexpression of EZR in ESCC cells
por: Zhang, Xiao-Dan, et al.
Publicado: (2018)

KDM4C, a H3K9me3 Histone Demethylase, is Involved in the Maintenance of Human ESCC-Initiating Cells by Epigenetically Enhancing SOX2 Expression()
por: Yuan, Xiang, et al.
Publicado: (2016)

Functional role of MicroRNA/PI3K/AKT axis in osteosarcoma
por: Xiang, Yubo, et al.
Publicado: (2023)

Prognostic Value of Combined Analysis of CTLA-4 and PLR in Esophageal Squamous Cell Carcinoma (ESCC) Patients
por: Zhang, Cui-Ying, et al.
Publicado: (2019)

Combination of meta-analysis and graph clustering to identify prognostic markers of ESCC
por: Gao, Hongyun, et al.
Publicado: (2012)

Transcriptomic and microRNA Expression Profiles Identify Biomarkers for Predicting Neo-Chemoradiotherapy Response in Esophageal Squamous Cell Carcinomas (ESCC)
por: Wang, Jian, et al.
Publicado: (2021)

Directional Migration in Esophageal Squamous Cell Carcinoma (ESCC) is Epigenetically Regulated by SET Nuclear Oncogene, a Member of the Inhibitor of Histone Acetyltransferase Complex()
por: Yuan, Xiang, et al.
Publicado: (2017)

The circRNA circADAMTS6 promotes progression of ESCC and correlates with prognosis
por: Bu, Jing, et al.
Publicado: (2022)

Delta-radiomics based on CT predicts pathologic complete response in ESCC treated with neoadjuvant immunochemotherapy and surgery
por: Li, Kaiyuan, et al.
Publicado: (2023)

Reply: Hookah, opium, and tobacco smoking in relation to ESCC
por: Malekzadeh, R, et al.
Publicado: (2009)

Abnormally high HIP1 expression is associated with metastatic behaviors and poor prognosis in ESCC
por: Sun, Ying, et al.
Publicado: (2021)

Genome‐wide gain‐of‐function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma
por: Xing, Hui, et al.
Publicado: (2022)

Comparative Clinical Efficacy of ‘Concurrent Chemoradiotherapy (CCRT) and Anlotinib’ Than CCRT in Patients with Locally Advanced ESCC
por: Wang, Gang, et al.
Publicado: (2022)

Using tools to engage health-care facilities (HCFS) in a global movement: World Health Organisation (WHO) Save Lives: Clean Your Hands (SL: CYHS) annual campaign
por: Kilpatrick, C, et al.
Publicado: (2011)

The Silencing of SFRP2 Expression in ESCC Is Due to Methylation of the Gene Promoter
por: Liu, Qian, et al.
Publicado: (2019)

Nrf2 promotes esophageal squamous cell carcinoma (ESCC) resistance to radiotherapy through the CaMKIIα-associated activation of autophagy
por: Xia, Di, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cqi94hmst0qmt92g40f669lepn