Cargando…
Laparoscopic sleeve gastrectomy alters (1)H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease
Patients with morbid obesity frequently present non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) associated with pro-atherogenic alterations. Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for weight reduction, and for the remission of hepatic alterations. U...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809416/ https://www.ncbi.nlm.nih.gov/pubmed/33446705 http://dx.doi.org/10.1038/s41598-020-79485-7 |
_version_ | 1783637117351493632 |
---|---|
author | Cabré, Noemí Gil, Míriam Amigó, Núria Luciano-Mateo, Fedra Baiges-Gaya, Gerard Fernández-Arroyo, Salvador Rodríguez-Tomàs, Elisabet Hernández-Aguilera, Anna Castañé, Helena París, Marta Sabench, Fàtima Del Castillo, Daniel Camps, Jordi Joven, Jorge |
author_facet | Cabré, Noemí Gil, Míriam Amigó, Núria Luciano-Mateo, Fedra Baiges-Gaya, Gerard Fernández-Arroyo, Salvador Rodríguez-Tomàs, Elisabet Hernández-Aguilera, Anna Castañé, Helena París, Marta Sabench, Fàtima Del Castillo, Daniel Camps, Jordi Joven, Jorge |
author_sort | Cabré, Noemí |
collection | PubMed |
description | Patients with morbid obesity frequently present non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) associated with pro-atherogenic alterations. Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for weight reduction, and for the remission of hepatic alterations. Using (1)H-nuclear magnetic resonance ((1)H-NMR), we investigated the effects of LSG on lipoprotein and glycoprotein profile in patients with morbid obesity and liver disease. We included 154 patients with morbid obesity (49 non-NASH, 54 uncertain NASH, 51 definite NASH). A blood sample was obtained before surgery and, in patients with definite NASH, one year after surgery. Patients with NASH had increased concentrations of medium and small VLDL particles, VLDL and IDL cholesterol concentrations, IDL, LDL, and HDL triglyceride concentrations, and elevated glycoprotein levels. These changes were more marked in patients with type 2 diabetes mellitus. LSG produced significant decreases in the concentration of VLDL particles, VLDL cholesterol and triglycerides, an increase in the concentration LDL particles and LDL cholesterol concentrations, and a decrease in protein glycation. We conclude that patients with obesity and NASH had significant alterations in circulating levels of lipoproteins and glycoproteins that were associated with the severity of the disease. Most of these changes were reversed post-LSG. |
format | Online Article Text |
id | pubmed-7809416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78094162021-01-21 Laparoscopic sleeve gastrectomy alters (1)H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease Cabré, Noemí Gil, Míriam Amigó, Núria Luciano-Mateo, Fedra Baiges-Gaya, Gerard Fernández-Arroyo, Salvador Rodríguez-Tomàs, Elisabet Hernández-Aguilera, Anna Castañé, Helena París, Marta Sabench, Fàtima Del Castillo, Daniel Camps, Jordi Joven, Jorge Sci Rep Article Patients with morbid obesity frequently present non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) associated with pro-atherogenic alterations. Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for weight reduction, and for the remission of hepatic alterations. Using (1)H-nuclear magnetic resonance ((1)H-NMR), we investigated the effects of LSG on lipoprotein and glycoprotein profile in patients with morbid obesity and liver disease. We included 154 patients with morbid obesity (49 non-NASH, 54 uncertain NASH, 51 definite NASH). A blood sample was obtained before surgery and, in patients with definite NASH, one year after surgery. Patients with NASH had increased concentrations of medium and small VLDL particles, VLDL and IDL cholesterol concentrations, IDL, LDL, and HDL triglyceride concentrations, and elevated glycoprotein levels. These changes were more marked in patients with type 2 diabetes mellitus. LSG produced significant decreases in the concentration of VLDL particles, VLDL cholesterol and triglycerides, an increase in the concentration LDL particles and LDL cholesterol concentrations, and a decrease in protein glycation. We conclude that patients with obesity and NASH had significant alterations in circulating levels of lipoproteins and glycoproteins that were associated with the severity of the disease. Most of these changes were reversed post-LSG. Nature Publishing Group UK 2021-01-14 /pmc/articles/PMC7809416/ /pubmed/33446705 http://dx.doi.org/10.1038/s41598-020-79485-7 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Cabré, Noemí Gil, Míriam Amigó, Núria Luciano-Mateo, Fedra Baiges-Gaya, Gerard Fernández-Arroyo, Salvador Rodríguez-Tomàs, Elisabet Hernández-Aguilera, Anna Castañé, Helena París, Marta Sabench, Fàtima Del Castillo, Daniel Camps, Jordi Joven, Jorge Laparoscopic sleeve gastrectomy alters (1)H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease |
title | Laparoscopic sleeve gastrectomy alters (1)H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease |
title_full | Laparoscopic sleeve gastrectomy alters (1)H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease |
title_fullStr | Laparoscopic sleeve gastrectomy alters (1)H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease |
title_full_unstemmed | Laparoscopic sleeve gastrectomy alters (1)H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease |
title_short | Laparoscopic sleeve gastrectomy alters (1)H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease |
title_sort | laparoscopic sleeve gastrectomy alters (1)h-nmr-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809416/ https://www.ncbi.nlm.nih.gov/pubmed/33446705 http://dx.doi.org/10.1038/s41598-020-79485-7 |
work_keys_str_mv | AT cabrenoemi laparoscopicsleevegastrectomyalters1hnmrmeasuredlipoproteinandglycoproteinprofileinpatientswithsevereobesityandnonalcoholicfattyliverdisease AT gilmiriam laparoscopicsleevegastrectomyalters1hnmrmeasuredlipoproteinandglycoproteinprofileinpatientswithsevereobesityandnonalcoholicfattyliverdisease AT amigonuria laparoscopicsleevegastrectomyalters1hnmrmeasuredlipoproteinandglycoproteinprofileinpatientswithsevereobesityandnonalcoholicfattyliverdisease AT lucianomateofedra laparoscopicsleevegastrectomyalters1hnmrmeasuredlipoproteinandglycoproteinprofileinpatientswithsevereobesityandnonalcoholicfattyliverdisease AT baigesgayagerard laparoscopicsleevegastrectomyalters1hnmrmeasuredlipoproteinandglycoproteinprofileinpatientswithsevereobesityandnonalcoholicfattyliverdisease AT fernandezarroyosalvador laparoscopicsleevegastrectomyalters1hnmrmeasuredlipoproteinandglycoproteinprofileinpatientswithsevereobesityandnonalcoholicfattyliverdisease AT rodrigueztomaselisabet laparoscopicsleevegastrectomyalters1hnmrmeasuredlipoproteinandglycoproteinprofileinpatientswithsevereobesityandnonalcoholicfattyliverdisease AT hernandezaguileraanna laparoscopicsleevegastrectomyalters1hnmrmeasuredlipoproteinandglycoproteinprofileinpatientswithsevereobesityandnonalcoholicfattyliverdisease AT castanehelena laparoscopicsleevegastrectomyalters1hnmrmeasuredlipoproteinandglycoproteinprofileinpatientswithsevereobesityandnonalcoholicfattyliverdisease AT parismarta laparoscopicsleevegastrectomyalters1hnmrmeasuredlipoproteinandglycoproteinprofileinpatientswithsevereobesityandnonalcoholicfattyliverdisease AT sabenchfatima laparoscopicsleevegastrectomyalters1hnmrmeasuredlipoproteinandglycoproteinprofileinpatientswithsevereobesityandnonalcoholicfattyliverdisease AT delcastillodaniel laparoscopicsleevegastrectomyalters1hnmrmeasuredlipoproteinandglycoproteinprofileinpatientswithsevereobesityandnonalcoholicfattyliverdisease AT campsjordi laparoscopicsleevegastrectomyalters1hnmrmeasuredlipoproteinandglycoproteinprofileinpatientswithsevereobesityandnonalcoholicfattyliverdisease AT jovenjorge laparoscopicsleevegastrectomyalters1hnmrmeasuredlipoproteinandglycoproteinprofileinpatientswithsevereobesityandnonalcoholicfattyliverdisease |