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Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants
This study aimed to elaborate upon prior findings suggestive of the altered lateralization of structural connectivity in the developing preterm brain by using diffusion tensor imaging tractography to explore how network topological asymmetries in fronto-limbic neural circuitry are altered at 36–41 w...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809421/ https://www.ncbi.nlm.nih.gov/pubmed/33446672 http://dx.doi.org/10.1038/s41598-020-79446-0 |
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author | Lee, Joo Young Choi, Yong-Ho Cha, Jong Ho Lee, Ji Young Lee, Young-Jun Kim, Bo-Hyun Kim, Il-Kewon Lee, Jong-Min Lee, Hyun Ju |
author_facet | Lee, Joo Young Choi, Yong-Ho Cha, Jong Ho Lee, Ji Young Lee, Young-Jun Kim, Bo-Hyun Kim, Il-Kewon Lee, Jong-Min Lee, Hyun Ju |
author_sort | Lee, Joo Young |
collection | PubMed |
description | This study aimed to elaborate upon prior findings suggestive of the altered lateralization of structural connectivity in the developing preterm brain by using diffusion tensor imaging tractography to explore how network topological asymmetries in fronto-limbic neural circuitry are altered at 36–41 weeks, postmenstrual age in 64 preterm infants without severe brain injury and 33 term-born infants. We compared the pattern of structural connectivity and network lateralization of the betweenness centrality in the medial fronto-orbital gyrus, superior temporal gyrus, amygdala, and hippocampus—the structures comprising the fronto-limbic brain circuit—between preterm and term infants. Global efficiency, local efficiency, and small-world characteristics did not differ significantly between the two hemispheres in term-born infants, suggesting that integration and segregation are balanced between the left and right hemispheres. However, the preterm brain showed significantly greater leftward lateralization of small-worldness (P = 0.033); the lateralization index of the betweenness centrality revealed that the medial fronto-orbital gyrus (P = 0.008), superior temporal gyrus (P = 0.031), and hippocampus (P = 0.028) showed significantly increased leftward asymmetry in preterm infants relative to term-infants independent of sex, age at imaging, and bronchopulmonary dysplasia. The altered lateralization of fronto-limbic brain circuitry might be involved in the early development of social–emotional disorders in preterm infants. |
format | Online Article Text |
id | pubmed-7809421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78094212021-01-21 Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants Lee, Joo Young Choi, Yong-Ho Cha, Jong Ho Lee, Ji Young Lee, Young-Jun Kim, Bo-Hyun Kim, Il-Kewon Lee, Jong-Min Lee, Hyun Ju Sci Rep Article This study aimed to elaborate upon prior findings suggestive of the altered lateralization of structural connectivity in the developing preterm brain by using diffusion tensor imaging tractography to explore how network topological asymmetries in fronto-limbic neural circuitry are altered at 36–41 weeks, postmenstrual age in 64 preterm infants without severe brain injury and 33 term-born infants. We compared the pattern of structural connectivity and network lateralization of the betweenness centrality in the medial fronto-orbital gyrus, superior temporal gyrus, amygdala, and hippocampus—the structures comprising the fronto-limbic brain circuit—between preterm and term infants. Global efficiency, local efficiency, and small-world characteristics did not differ significantly between the two hemispheres in term-born infants, suggesting that integration and segregation are balanced between the left and right hemispheres. However, the preterm brain showed significantly greater leftward lateralization of small-worldness (P = 0.033); the lateralization index of the betweenness centrality revealed that the medial fronto-orbital gyrus (P = 0.008), superior temporal gyrus (P = 0.031), and hippocampus (P = 0.028) showed significantly increased leftward asymmetry in preterm infants relative to term-infants independent of sex, age at imaging, and bronchopulmonary dysplasia. The altered lateralization of fronto-limbic brain circuitry might be involved in the early development of social–emotional disorders in preterm infants. Nature Publishing Group UK 2021-01-14 /pmc/articles/PMC7809421/ /pubmed/33446672 http://dx.doi.org/10.1038/s41598-020-79446-0 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Lee, Joo Young Choi, Yong-Ho Cha, Jong Ho Lee, Ji Young Lee, Young-Jun Kim, Bo-Hyun Kim, Il-Kewon Lee, Jong-Min Lee, Hyun Ju Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants |
title | Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants |
title_full | Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants |
title_fullStr | Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants |
title_full_unstemmed | Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants |
title_short | Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants |
title_sort | altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809421/ https://www.ncbi.nlm.nih.gov/pubmed/33446672 http://dx.doi.org/10.1038/s41598-020-79446-0 |
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