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Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study

Higher mortality in asthmatics has been shown previously. However, evidence on different asthma phenotypes on long-term mortality risk is limited. The aim was to evaluate the impact of asthma phenotypes on mortality in general population. Data from the National Health and Nutrition Examination Surve...

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Autores principales: He, Xumei, Cheng, GeSheng, He, Lu, Liao, Bing, Du, YaJuan, Xie, Xuegang, Zhang, Songlin, Li, Gang, Wang, Yafeng, Zhang, YuShun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809422/
https://www.ncbi.nlm.nih.gov/pubmed/33446724
http://dx.doi.org/10.1038/s41598-020-79264-4
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author He, Xumei
Cheng, GeSheng
He, Lu
Liao, Bing
Du, YaJuan
Xie, Xuegang
Zhang, Songlin
Li, Gang
Wang, Yafeng
Zhang, YuShun
author_facet He, Xumei
Cheng, GeSheng
He, Lu
Liao, Bing
Du, YaJuan
Xie, Xuegang
Zhang, Songlin
Li, Gang
Wang, Yafeng
Zhang, YuShun
author_sort He, Xumei
collection PubMed
description Higher mortality in asthmatics has been shown previously. However, evidence on different asthma phenotypes on long-term mortality risk is limited. The aim was to evaluate the impact of asthma phenotypes on mortality in general population. Data from the National Health and Nutrition Examination Survey from 2001–2002 to 2013–2014 linked mortality files through December 31, 2015, were used (N = 37,015). Cox proportional hazards regression was used to estimate the risk of all-cause and cause-specific mortality adjusting for sociodemographic characteristics, smoking, body mass index, and chronic conditions. During the mean follow-up time of 7.5 years, 4326 participants died from a variety of causes. Current asthma, but not former asthma was associated with increased all-cause mortality (current asthma: HR = 1.37; 95% CI 1.20–1.58; Former asthma: HR = 0.93; 95% CI 0.73–1.18); as well as mortality from cardiovascular disease (HR(Current) = 1.41; 95% CI 1.08–1.85) and chronic lower respiratory diseases (HR(Current) = 3.17; 95% CI 1.96–5.14). In addition, we found that the HR for cardiovascular disease (CVD) mortality was slightly greater in people with childhood-onset asthma than those with adult-onset asthma. The HR for chronic lower respiratory diseases (CLRD) mortality was greater in people with adult-onset asthma than those with childhood-onset asthma. However, the differences were not statistically significant. Our study suggested that current asthma but not former asthma was associated with increased all-cause, CLRD and CVD mortality. Future well-designed studies with larger sample are required to demonstrate the association and clarify the potential mechanisms involved.
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spelling pubmed-78094222021-01-21 Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study He, Xumei Cheng, GeSheng He, Lu Liao, Bing Du, YaJuan Xie, Xuegang Zhang, Songlin Li, Gang Wang, Yafeng Zhang, YuShun Sci Rep Article Higher mortality in asthmatics has been shown previously. However, evidence on different asthma phenotypes on long-term mortality risk is limited. The aim was to evaluate the impact of asthma phenotypes on mortality in general population. Data from the National Health and Nutrition Examination Survey from 2001–2002 to 2013–2014 linked mortality files through December 31, 2015, were used (N = 37,015). Cox proportional hazards regression was used to estimate the risk of all-cause and cause-specific mortality adjusting for sociodemographic characteristics, smoking, body mass index, and chronic conditions. During the mean follow-up time of 7.5 years, 4326 participants died from a variety of causes. Current asthma, but not former asthma was associated with increased all-cause mortality (current asthma: HR = 1.37; 95% CI 1.20–1.58; Former asthma: HR = 0.93; 95% CI 0.73–1.18); as well as mortality from cardiovascular disease (HR(Current) = 1.41; 95% CI 1.08–1.85) and chronic lower respiratory diseases (HR(Current) = 3.17; 95% CI 1.96–5.14). In addition, we found that the HR for cardiovascular disease (CVD) mortality was slightly greater in people with childhood-onset asthma than those with adult-onset asthma. The HR for chronic lower respiratory diseases (CLRD) mortality was greater in people with adult-onset asthma than those with childhood-onset asthma. However, the differences were not statistically significant. Our study suggested that current asthma but not former asthma was associated with increased all-cause, CLRD and CVD mortality. Future well-designed studies with larger sample are required to demonstrate the association and clarify the potential mechanisms involved. Nature Publishing Group UK 2021-01-14 /pmc/articles/PMC7809422/ /pubmed/33446724 http://dx.doi.org/10.1038/s41598-020-79264-4 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
He, Xumei
Cheng, GeSheng
He, Lu
Liao, Bing
Du, YaJuan
Xie, Xuegang
Zhang, Songlin
Li, Gang
Wang, Yafeng
Zhang, YuShun
Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study
title Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study
title_full Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study
title_fullStr Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study
title_full_unstemmed Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study
title_short Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study
title_sort adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809422/
https://www.ncbi.nlm.nih.gov/pubmed/33446724
http://dx.doi.org/10.1038/s41598-020-79264-4
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