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Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model

Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divid...

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Autores principales: Hegyi, Péter J., Soós, Alexandra, Tóth, Emese, Ébert, Attila, Venglovecz, Viktória, Márta, Katalin, Mátrai, Péter, Mikó, Alexandra, Bajor, Judit, Sarlós, Patrícia, Vincze, Áron, Halász, Adrienn, Izbéki, Ferenc, Szepes, Zoltán, Czakó, László, Kovács, György, Papp, Mária, Dubravcsik, Zsolt, Varga, Márta, Hamvas, József, Németh, Balázs C., Macarie, Melania, Ince, Ali Tüzün, Bordin, Dmitry S., Dubtsova, Elena A., Kiryukova, Mariya A., Khatkov, Igor E., Bideeva, Tanya, Mickevicius, Artautas, Ramírez-Maldonado, Elena, Sallinen, Ville, Erőss, Bálint, Pécsi, Dániel, Szentesi, Andrea, Párniczky, Andrea, Tiszlavicz, László, Hegyi, Péter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809468/
https://www.ncbi.nlm.nih.gov/pubmed/33446814
http://dx.doi.org/10.1038/s41598-020-80532-6
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author Hegyi, Péter J.
Soós, Alexandra
Tóth, Emese
Ébert, Attila
Venglovecz, Viktória
Márta, Katalin
Mátrai, Péter
Mikó, Alexandra
Bajor, Judit
Sarlós, Patrícia
Vincze, Áron
Halász, Adrienn
Izbéki, Ferenc
Szepes, Zoltán
Czakó, László
Kovács, György
Papp, Mária
Dubravcsik, Zsolt
Varga, Márta
Hamvas, József
Németh, Balázs C.
Macarie, Melania
Ince, Ali Tüzün
Bordin, Dmitry S.
Dubtsova, Elena A.
Kiryukova, Mariya A.
Khatkov, Igor E.
Bideeva, Tanya
Mickevicius, Artautas
Ramírez-Maldonado, Elena
Sallinen, Ville
Erőss, Bálint
Pécsi, Dániel
Szentesi, Andrea
Párniczky, Andrea
Tiszlavicz, László
Hegyi, Péter
author_facet Hegyi, Péter J.
Soós, Alexandra
Tóth, Emese
Ébert, Attila
Venglovecz, Viktória
Márta, Katalin
Mátrai, Péter
Mikó, Alexandra
Bajor, Judit
Sarlós, Patrícia
Vincze, Áron
Halász, Adrienn
Izbéki, Ferenc
Szepes, Zoltán
Czakó, László
Kovács, György
Papp, Mária
Dubravcsik, Zsolt
Varga, Márta
Hamvas, József
Németh, Balázs C.
Macarie, Melania
Ince, Ali Tüzün
Bordin, Dmitry S.
Dubtsova, Elena A.
Kiryukova, Mariya A.
Khatkov, Igor E.
Bideeva, Tanya
Mickevicius, Artautas
Ramírez-Maldonado, Elena
Sallinen, Ville
Erőss, Bálint
Pécsi, Dániel
Szentesi, Andrea
Párniczky, Andrea
Tiszlavicz, László
Hegyi, Péter
author_sort Hegyi, Péter J.
collection PubMed
description Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare.
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spelling pubmed-78094682021-01-21 Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model Hegyi, Péter J. Soós, Alexandra Tóth, Emese Ébert, Attila Venglovecz, Viktória Márta, Katalin Mátrai, Péter Mikó, Alexandra Bajor, Judit Sarlós, Patrícia Vincze, Áron Halász, Adrienn Izbéki, Ferenc Szepes, Zoltán Czakó, László Kovács, György Papp, Mária Dubravcsik, Zsolt Varga, Márta Hamvas, József Németh, Balázs C. Macarie, Melania Ince, Ali Tüzün Bordin, Dmitry S. Dubtsova, Elena A. Kiryukova, Mariya A. Khatkov, Igor E. Bideeva, Tanya Mickevicius, Artautas Ramírez-Maldonado, Elena Sallinen, Ville Erőss, Bálint Pécsi, Dániel Szentesi, Andrea Párniczky, Andrea Tiszlavicz, László Hegyi, Péter Sci Rep Article Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare. Nature Publishing Group UK 2021-01-14 /pmc/articles/PMC7809468/ /pubmed/33446814 http://dx.doi.org/10.1038/s41598-020-80532-6 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hegyi, Péter J.
Soós, Alexandra
Tóth, Emese
Ébert, Attila
Venglovecz, Viktória
Márta, Katalin
Mátrai, Péter
Mikó, Alexandra
Bajor, Judit
Sarlós, Patrícia
Vincze, Áron
Halász, Adrienn
Izbéki, Ferenc
Szepes, Zoltán
Czakó, László
Kovács, György
Papp, Mária
Dubravcsik, Zsolt
Varga, Márta
Hamvas, József
Németh, Balázs C.
Macarie, Melania
Ince, Ali Tüzün
Bordin, Dmitry S.
Dubtsova, Elena A.
Kiryukova, Mariya A.
Khatkov, Igor E.
Bideeva, Tanya
Mickevicius, Artautas
Ramírez-Maldonado, Elena
Sallinen, Ville
Erőss, Bálint
Pécsi, Dániel
Szentesi, Andrea
Párniczky, Andrea
Tiszlavicz, László
Hegyi, Péter
Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model
title Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model
title_full Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model
title_fullStr Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model
title_full_unstemmed Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model
title_short Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model
title_sort evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809468/
https://www.ncbi.nlm.nih.gov/pubmed/33446814
http://dx.doi.org/10.1038/s41598-020-80532-6
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