Research progress of the transcription factor Brn4

Brain 4 (Brn4) is a transcription factor belonging to the POU3 family, and it is important for the embryonic development of the neural tube, inner ear and pancreas. In addition, it serves a crucial role in neural stem cell differentiation and reprogramming. The present review aimed to summarize the...

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Autores principales: Wu, Yuying, Zhang, Xunrui, Wang, Jue, Jin, Guohua, Zhang, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809911/
https://www.ncbi.nlm.nih.gov/pubmed/33398372
http://dx.doi.org/10.3892/mmr.2020.11818
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author Wu, Yuying
Zhang, Xunrui
Wang, Jue
Jin, Guohua
Zhang, Xinhua
author_facet Wu, Yuying
Zhang, Xunrui
Wang, Jue
Jin, Guohua
Zhang, Xinhua
author_sort Wu, Yuying
collection PubMed
description Brain 4 (Brn4) is a transcription factor belonging to the POU3 family, and it is important for the embryonic development of the neural tube, inner ear and pancreas. In addition, it serves a crucial role in neural stem cell differentiation and reprogramming. The present review aimed to summarize the chromosomal location, species homology, protein molecular structure and tissue distribution of Brn4, in addition to its biological processes, with the aim of providing a reference of its structure and function for further studies, and its potential use as a gene therapy target.
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spelling pubmed-78099112021-01-21 Research progress of the transcription factor Brn4 Wu, Yuying Zhang, Xunrui Wang, Jue Jin, Guohua Zhang, Xinhua Mol Med Rep Review Brain 4 (Brn4) is a transcription factor belonging to the POU3 family, and it is important for the embryonic development of the neural tube, inner ear and pancreas. In addition, it serves a crucial role in neural stem cell differentiation and reprogramming. The present review aimed to summarize the chromosomal location, species homology, protein molecular structure and tissue distribution of Brn4, in addition to its biological processes, with the aim of providing a reference of its structure and function for further studies, and its potential use as a gene therapy target. D.A. Spandidos 2021-03 2020-12-31 /pmc/articles/PMC7809911/ /pubmed/33398372 http://dx.doi.org/10.3892/mmr.2020.11818 Text en Copyright: © Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Wu, Yuying
Zhang, Xunrui
Wang, Jue
Jin, Guohua
Zhang, Xinhua
Research progress of the transcription factor Brn4
title Research progress of the transcription factor Brn4
title_full Research progress of the transcription factor Brn4
title_fullStr Research progress of the transcription factor Brn4
title_full_unstemmed Research progress of the transcription factor Brn4
title_short Research progress of the transcription factor Brn4
title_sort research progress of the transcription factor brn4
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809911/
https://www.ncbi.nlm.nih.gov/pubmed/33398372
http://dx.doi.org/10.3892/mmr.2020.11818
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