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Influence of post-stroke fatigue on reaction times and corticospinal excitability during movement preparation

OBJECTIVES: Reduced corticospinal excitability at rest is associated with post-stroke fatigue (PSF). However, it is not known if corticospinal excitability prior to a movement is also altered in fatigue which may then influence subsequent behaviour. We hypothesized that the levels of PSF can be expl...

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Autores principales: De Doncker, William, Brown, Katlyn E., Kuppuswamy, Annapoorna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810236/
https://www.ncbi.nlm.nih.gov/pubmed/33302061
http://dx.doi.org/10.1016/j.clinph.2020.11.012
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author De Doncker, William
Brown, Katlyn E.
Kuppuswamy, Annapoorna
author_facet De Doncker, William
Brown, Katlyn E.
Kuppuswamy, Annapoorna
author_sort De Doncker, William
collection PubMed
description OBJECTIVES: Reduced corticospinal excitability at rest is associated with post-stroke fatigue (PSF). However, it is not known if corticospinal excitability prior to a movement is also altered in fatigue which may then influence subsequent behaviour. We hypothesized that the levels of PSF can be explained by differences in modulation of corticospinal excitability during movement preparation. METHODS: 73 stroke survivors performed an auditory reaction time task. Corticospinal excitability was measured using transcranial magnetic stimulation. Fatigue was quantified using the fatigue severity scale. The effect of time and fatigue on corticospinal excitability and reaction time was analysed using a mixed effects model. RESULTS: Those with greater levels of PSF showed reduced suppression of corticospinal excitability during movement preparation and increased facilitation immediately prior to movement onset (β = −0.0066, t = −2.22, p = 0.0263). Greater the fatigue, slower the reaction times the closer the stimulation time to movement onset (β = 0.0024, t = 2.47, p = 0.0159). CONCLUSIONS: Lack of pre-movement modulation of corticospinal excitability in high fatigue may indicate poor sensory processing supporting the sensory attenuation model of fatigue. SIGNIFICANCE: We take a systems-based approach and investigate the motor system and its role in pathological fatigue allowing us to move towards gaining a mechanistic understanding of chronic pathological fatigue.
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spelling pubmed-78102362021-01-22 Influence of post-stroke fatigue on reaction times and corticospinal excitability during movement preparation De Doncker, William Brown, Katlyn E. Kuppuswamy, Annapoorna Clin Neurophysiol Article OBJECTIVES: Reduced corticospinal excitability at rest is associated with post-stroke fatigue (PSF). However, it is not known if corticospinal excitability prior to a movement is also altered in fatigue which may then influence subsequent behaviour. We hypothesized that the levels of PSF can be explained by differences in modulation of corticospinal excitability during movement preparation. METHODS: 73 stroke survivors performed an auditory reaction time task. Corticospinal excitability was measured using transcranial magnetic stimulation. Fatigue was quantified using the fatigue severity scale. The effect of time and fatigue on corticospinal excitability and reaction time was analysed using a mixed effects model. RESULTS: Those with greater levels of PSF showed reduced suppression of corticospinal excitability during movement preparation and increased facilitation immediately prior to movement onset (β = −0.0066, t = −2.22, p = 0.0263). Greater the fatigue, slower the reaction times the closer the stimulation time to movement onset (β = 0.0024, t = 2.47, p = 0.0159). CONCLUSIONS: Lack of pre-movement modulation of corticospinal excitability in high fatigue may indicate poor sensory processing supporting the sensory attenuation model of fatigue. SIGNIFICANCE: We take a systems-based approach and investigate the motor system and its role in pathological fatigue allowing us to move towards gaining a mechanistic understanding of chronic pathological fatigue. Elsevier 2021-01 /pmc/articles/PMC7810236/ /pubmed/33302061 http://dx.doi.org/10.1016/j.clinph.2020.11.012 Text en © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
De Doncker, William
Brown, Katlyn E.
Kuppuswamy, Annapoorna
Influence of post-stroke fatigue on reaction times and corticospinal excitability during movement preparation
title Influence of post-stroke fatigue on reaction times and corticospinal excitability during movement preparation
title_full Influence of post-stroke fatigue on reaction times and corticospinal excitability during movement preparation
title_fullStr Influence of post-stroke fatigue on reaction times and corticospinal excitability during movement preparation
title_full_unstemmed Influence of post-stroke fatigue on reaction times and corticospinal excitability during movement preparation
title_short Influence of post-stroke fatigue on reaction times and corticospinal excitability during movement preparation
title_sort influence of post-stroke fatigue on reaction times and corticospinal excitability during movement preparation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810236/
https://www.ncbi.nlm.nih.gov/pubmed/33302061
http://dx.doi.org/10.1016/j.clinph.2020.11.012
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