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An overlapping case of in situ mantle cell neoplasia and leukemic non-nodal mantle cell lymphoma

In situ mantle cell neoplasia (isMCN) and leukemic non-nodal mantle cell lymphoma (nnMCL) are classified as an indolent subtype of mantle cell lymphoma (MCL). The tumor cells of isMCN are restricted to the inner layer of the lymphoid tissue mantle zone, exhibiting an in situ pattern histologically....

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Autores principales: Matsuoka, Ryota, Sakamoto, Noriaki, Sakata-Yanagimoto, Mamiko, Chiba, Shigeru, Noguchi, Masayuki, Nakamura, Naoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JSLRT 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810252/
https://www.ncbi.nlm.nih.gov/pubmed/33028761
http://dx.doi.org/10.3960/jslrt.20022
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author Matsuoka, Ryota
Sakamoto, Noriaki
Sakata-Yanagimoto, Mamiko
Chiba, Shigeru
Noguchi, Masayuki
Nakamura, Naoya
author_facet Matsuoka, Ryota
Sakamoto, Noriaki
Sakata-Yanagimoto, Mamiko
Chiba, Shigeru
Noguchi, Masayuki
Nakamura, Naoya
author_sort Matsuoka, Ryota
collection PubMed
description In situ mantle cell neoplasia (isMCN) and leukemic non-nodal mantle cell lymphoma (nnMCL) are classified as an indolent subtype of mantle cell lymphoma (MCL). The tumor cells of isMCN are restricted to the inner layer of the lymphoid tissue mantle zone, exhibiting an in situ pattern histologically. On the other hand, nnMCL is distributed in the peripheral blood, bone marrow and sometimes the spleen, but lymphadenopathy or systemic organ involvement is rare. We report a case of isMCN in a submandibular lymph node resected from a 65-year-old Japanese male. The tumor cells were positive for cyclin D1 (CCND1) and SOX11 expression, and were restricted to the mantle zone area of the lymph node. However, tumor cells were also detected in the stomach mucosa, bone marrow tissue and peripheral blood, suggesting nnMCL. isMCN and nnMCL may have a partly overlapping disease spectrum, although the correlation between these two subtypes has not been well described. This present case demonstrated characteristics overlapping between isMCN and nnMCL.
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spelling pubmed-78102522021-01-19 An overlapping case of in situ mantle cell neoplasia and leukemic non-nodal mantle cell lymphoma Matsuoka, Ryota Sakamoto, Noriaki Sakata-Yanagimoto, Mamiko Chiba, Shigeru Noguchi, Masayuki Nakamura, Naoya J Clin Exp Hematop Case Report In situ mantle cell neoplasia (isMCN) and leukemic non-nodal mantle cell lymphoma (nnMCL) are classified as an indolent subtype of mantle cell lymphoma (MCL). The tumor cells of isMCN are restricted to the inner layer of the lymphoid tissue mantle zone, exhibiting an in situ pattern histologically. On the other hand, nnMCL is distributed in the peripheral blood, bone marrow and sometimes the spleen, but lymphadenopathy or systemic organ involvement is rare. We report a case of isMCN in a submandibular lymph node resected from a 65-year-old Japanese male. The tumor cells were positive for cyclin D1 (CCND1) and SOX11 expression, and were restricted to the mantle zone area of the lymph node. However, tumor cells were also detected in the stomach mucosa, bone marrow tissue and peripheral blood, suggesting nnMCL. isMCN and nnMCL may have a partly overlapping disease spectrum, although the correlation between these two subtypes has not been well described. This present case demonstrated characteristics overlapping between isMCN and nnMCL. JSLRT 2020-10-08 /pmc/articles/PMC7810252/ /pubmed/33028761 http://dx.doi.org/10.3960/jslrt.20022 Text en © 2020 by The Japanese Society for Lymphoreticular Tissue Research https://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution ShareAlike (CC BY-NC-SA) 4.0 License.
spellingShingle Case Report
Matsuoka, Ryota
Sakamoto, Noriaki
Sakata-Yanagimoto, Mamiko
Chiba, Shigeru
Noguchi, Masayuki
Nakamura, Naoya
An overlapping case of in situ mantle cell neoplasia and leukemic non-nodal mantle cell lymphoma
title An overlapping case of in situ mantle cell neoplasia and leukemic non-nodal mantle cell lymphoma
title_full An overlapping case of in situ mantle cell neoplasia and leukemic non-nodal mantle cell lymphoma
title_fullStr An overlapping case of in situ mantle cell neoplasia and leukemic non-nodal mantle cell lymphoma
title_full_unstemmed An overlapping case of in situ mantle cell neoplasia and leukemic non-nodal mantle cell lymphoma
title_short An overlapping case of in situ mantle cell neoplasia and leukemic non-nodal mantle cell lymphoma
title_sort overlapping case of in situ mantle cell neoplasia and leukemic non-nodal mantle cell lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810252/
https://www.ncbi.nlm.nih.gov/pubmed/33028761
http://dx.doi.org/10.3960/jslrt.20022
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