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Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types

Despite the considerable progress in unraveling the genetic causes of amyotrophic lateral sclerosis (ALS), we do not fully understand the molecular mechanisms underlying the disease. We analyzed genome-wide data involving 78,500 individuals using a polygenic risk score approach to identify the biolo...

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Detalles Bibliográficos
Autores principales:	Saez-Atienzar, Sara, Bandres-Ciga, Sara, Langston, Rebekah G., Kim, Jonggeol J., Choi, Shing Wan, Reynolds, Regina H., Abramzon, Yevgeniya, Dewan, Ramita, Ahmed, Sarah, Landers, John E., Chia, Ruth, Ryten, Mina, Cookson, Mark R., Nalls, Michael A., Chiò, Adriano, Traynor, Bryan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810371/ https://www.ncbi.nlm.nih.gov/pubmed/33523907 http://dx.doi.org/10.1126/sciadv.abd9036

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