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Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module

The Cdk8 kinase module (CKM) in Mediator, comprising Med13, Med12, CycC, and Cdk8, regulates RNA polymerase II transcription through kinase-dependent and -independent functions. Numerous pathogenic mutations causative for neurodevelopmental disorders and cancer congregate in CKM subunits. However, t...

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Detalles Bibliográficos
Autores principales:	Li, Yi-Chuan, Chao, Ti-Chun, Kim, Hee Jong, Cholko, Timothy, Chen, Shin-Fu, Li, Guojie, Snyder, Laura, Nakanishi, Kotaro, Chang, Chia-en, Murakami, Kenji, Garcia, Benjamin A., Boyer, Thomas G., Tsai, Kuang-Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810384/ https://www.ncbi.nlm.nih.gov/pubmed/33523904 http://dx.doi.org/10.1126/sciadv.abd4484

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