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Clinical responses to PD-1 inhibition and their molecular characterization in six patients with mismatch repair-deficient metastatic cancer of the digestive system

PURPOSE: Immune checkpoint inhibitors have shown efficacy in patients with microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) gastrointestinal (GI) cancers. However, depth and duration of clinical response is not uniform. We assessed tumor mutation burden (TMB) as a response mark...

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Detalles Bibliográficos
Autores principales:	Hirsch, Daniela, Gaiser, Timo, Merx, Kirsten, Weingaertner, Simone, Forster, Michael, Hendricks, Alexander, Woenckhaus, Matthias, Schubert, Thomas, Hofheinz, Ralf-Dieter, Gencer, Deniz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Original Article – Clinical Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810640/ https://www.ncbi.nlm.nih.gov/pubmed/32776177 http://dx.doi.org/10.1007/s00432-020-03335-2

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