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Roflumilast Attenuates Doxorubicin-Induced Cardiotoxicity by Targeting Inflammation and Cellular Senescence in Cardiomyocytes Mediated by SIRT1

BACKGROUND AND PURPOSE: Cardiotoxicity is an important side effect of the treatment of a malignant tumor with Doxorubicin. Currently, decreasing the dosage of Doxorubicin to alleviate the side effects on cardiac function is the common method to deal with the cardiotoxicity induced by Doxorubicin. Th...

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Detalles Bibliográficos
Autores principales:	Zhang, Sheng, Wu, Peng, Liu, Jiabao, Du, Yingqiang, Yang, Zhijian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810683/ https://www.ncbi.nlm.nih.gov/pubmed/33469262 http://dx.doi.org/10.2147/DDDT.S269029

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