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OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1

Cancer cells develop protective adaptations against oxidative DNA damage, providing a strong rationale for targeting DNA repair proteins. There has been a high degree of recent interest in inhibiting the mammalian Nudix pyrophosphatase MutT Homolog 1 (MTH1). MTH1 degrades 8-oxo-dGTP, thus limiting i...

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Detalles Bibliográficos
Autores principales:	Zhang, Ling, Misiara, Laura, Samaranayake, Govindi J., Sharma, Nisha, Nguyen, Dao M., Tahara, Yu-Ki, Kool, Eric T., Rai, Priyamvada
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810763/ https://www.ncbi.nlm.nih.gov/pubmed/33450725 http://dx.doi.org/10.1016/j.redox.2020.101848

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