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CD14+ monocytes repress gamma globin expression at early stages of erythropoiesis

In β-hemoglobinopathies, reactivation of gamma- at the expense of beta-globin is a prominent therapeutic option. Expression of the globin genes is not strictly intrinsically regulated during erythropoiesis, supported by the observation that fetal erythroid cells switch to adult hemoglobin expression...

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Detalles Bibliográficos
Autores principales:	Heshusius, Steven, Heideveld, Esther, von Lindern, Marieke, van den Akker, Emile
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810836/ https://www.ncbi.nlm.nih.gov/pubmed/33452379 http://dx.doi.org/10.1038/s41598-021-81060-7

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