Early stability and late random tumor progression of a HER2-positive primary breast cancer patient-derived xenograft

We established patient-derived xenografts (PDX) from human primary breast cancers and studied whether stability or progressive events occurred during long-term in vivo passages (up to 4 years) in severely immunodeficient mice. While most PDX showed stable biomarker expression and growth phenotype, a...

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Detalles Bibliográficos
Autores principales: Landuzzi, Lorena, Palladini, Arianna, Ceccarelli, Claudio, Asioli, Sofia, Nicoletti, Giordano, Giusti, Veronica, Ruzzi, Francesca, Ianzano, Marianna L., Scalambra, Laura, Laranga, Roberta, Balboni, Tania, Arigoni, Maddalena, Olivero, Martina, Calogero, Raffaele A., De Giovanni, Carla, Dall’Ora, Massimiliano, Di Oto, Enrico, Santini, Donatella, Foschini, Maria Pia, Cucchi, Maria Cristina, Zanotti, Simone, Taffurelli, Mario, Nanni, Patrizia, Lollini, Pier-Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810859/
https://www.ncbi.nlm.nih.gov/pubmed/33452364
http://dx.doi.org/10.1038/s41598-021-81085-y

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