CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia

Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and –relapse in B-...

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Autores principales: Lenk, Lennart, Carlet, Michela, Vogiatzi, Fotini, Spory, Lea, Winterberg, Dorothee, Cousins, Antony, Vossen-Gajcy, Michaela, Ibruli, Olta, Vokuhl, Christian, Cario, Gunnar, El Ayoubi, Omar, Kramer, Lisa, Ritgen, Matthias, Brüggemann, Monika, Häsler, Robert, Schrappe, Martin, Fuhrmann, Stephan, Halsey, Christina, Jeremias, Irmela, Hobeika, Elias, Jumaa, Hassan, Alsadeq, Ameera, Schewe, Denis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810877/
https://www.ncbi.nlm.nih.gov/pubmed/33452446
http://dx.doi.org/10.1038/s42003-020-01591-z
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author Lenk, Lennart
Carlet, Michela
Vogiatzi, Fotini
Spory, Lea
Winterberg, Dorothee
Cousins, Antony
Vossen-Gajcy, Michaela
Ibruli, Olta
Vokuhl, Christian
Cario, Gunnar
El Ayoubi, Omar
Kramer, Lisa
Ritgen, Matthias
Brüggemann, Monika
Häsler, Robert
Schrappe, Martin
Fuhrmann, Stephan
Halsey, Christina
Jeremias, Irmela
Hobeika, Elias
Jumaa, Hassan
Alsadeq, Ameera
Schewe, Denis M.
author_facet Lenk, Lennart
Carlet, Michela
Vogiatzi, Fotini
Spory, Lea
Winterberg, Dorothee
Cousins, Antony
Vossen-Gajcy, Michaela
Ibruli, Olta
Vokuhl, Christian
Cario, Gunnar
El Ayoubi, Omar
Kramer, Lisa
Ritgen, Matthias
Brüggemann, Monika
Häsler, Robert
Schrappe, Martin
Fuhrmann, Stephan
Halsey, Christina
Jeremias, Irmela
Hobeika, Elias
Jumaa, Hassan
Alsadeq, Ameera
Schewe, Denis M.
author_sort Lenk, Lennart
collection PubMed
description Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and –relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.
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spelling pubmed-78108772021-01-21 CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia Lenk, Lennart Carlet, Michela Vogiatzi, Fotini Spory, Lea Winterberg, Dorothee Cousins, Antony Vossen-Gajcy, Michaela Ibruli, Olta Vokuhl, Christian Cario, Gunnar El Ayoubi, Omar Kramer, Lisa Ritgen, Matthias Brüggemann, Monika Häsler, Robert Schrappe, Martin Fuhrmann, Stephan Halsey, Christina Jeremias, Irmela Hobeika, Elias Jumaa, Hassan Alsadeq, Ameera Schewe, Denis M. Commun Biol Article Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and –relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS. Nature Publishing Group UK 2021-01-15 /pmc/articles/PMC7810877/ /pubmed/33452446 http://dx.doi.org/10.1038/s42003-020-01591-z Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lenk, Lennart
Carlet, Michela
Vogiatzi, Fotini
Spory, Lea
Winterberg, Dorothee
Cousins, Antony
Vossen-Gajcy, Michaela
Ibruli, Olta
Vokuhl, Christian
Cario, Gunnar
El Ayoubi, Omar
Kramer, Lisa
Ritgen, Matthias
Brüggemann, Monika
Häsler, Robert
Schrappe, Martin
Fuhrmann, Stephan
Halsey, Christina
Jeremias, Irmela
Hobeika, Elias
Jumaa, Hassan
Alsadeq, Ameera
Schewe, Denis M.
CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia
title CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia
title_full CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia
title_fullStr CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia
title_full_unstemmed CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia
title_short CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia
title_sort cd79a promotes cns-infiltration and leukemia engraftment in pediatric b-cell precursor acute lymphoblastic leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810877/
https://www.ncbi.nlm.nih.gov/pubmed/33452446
http://dx.doi.org/10.1038/s42003-020-01591-z
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