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Premature ventricular contraction is associated with increased risk of atrial fibrillation: a nationwide population-based study
Premature ventricular contraction (PVC) and atrial fibrillation (AF) are common arrhythmias affecting 1–2% of the general population. During PVC, retrograde ventriculo-atrial activation can occur and act like an atrial ectopy. However, the clinical significance of this phenomenon is not fully unders...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810887/ https://www.ncbi.nlm.nih.gov/pubmed/33452389 http://dx.doi.org/10.1038/s41598-021-81229-0 |
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author | Kim, Yun Gi Han, Kyung-Do Choi, Jong-Il Choi, Yun Young Choi, Ha Young Shim, Jaemin Kim, Young-Hoon |
author_facet | Kim, Yun Gi Han, Kyung-Do Choi, Jong-Il Choi, Yun Young Choi, Ha Young Shim, Jaemin Kim, Young-Hoon |
author_sort | Kim, Yun Gi |
collection | PubMed |
description | Premature ventricular contraction (PVC) and atrial fibrillation (AF) are common arrhythmias affecting 1–2% of the general population. During PVC, retrograde ventriculo-atrial activation can occur and act like an atrial ectopy. However, the clinical significance of this phenomenon is not fully understood. We aimed to elucidate whether the clinical diagnosis of PVC can increase the risk of new-onset AF. We performed a nationwide population-based analysis using the Korean National Health Insurance Service database. A total of 9,537,713 people without prior history of PVC and AF were identified. Among these people, 4135 developed PVC in 2009, and people with and without PVC were followed until 2018. People who had PVC showed an increased risk of new-onset AF as compared with people without PVC (hazard ratio [HR] = 2.705; 95% confidence interval [CI] = 2.428–3.013; p < 0.001). The risk of ischemic stroke was also significantly increased in people with PVC (HR 1.160; 95% CI 1.048–1.284; p = 0.0041). New-onset AF developed in 72 people (19.3%) among 374 people with PVC who had ischemic stroke during their follow-up. A significant interaction was observed between PVC and age with people < 65 years at greater risk of new-onset AF for having PVC. In this observational analysis, the risk of new-onset AF and ischemic stroke was increased in people with PVC. Additional evaluation to identify AF in people with PVC can be helpful. |
format | Online Article Text |
id | pubmed-7810887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78108872021-01-21 Premature ventricular contraction is associated with increased risk of atrial fibrillation: a nationwide population-based study Kim, Yun Gi Han, Kyung-Do Choi, Jong-Il Choi, Yun Young Choi, Ha Young Shim, Jaemin Kim, Young-Hoon Sci Rep Article Premature ventricular contraction (PVC) and atrial fibrillation (AF) are common arrhythmias affecting 1–2% of the general population. During PVC, retrograde ventriculo-atrial activation can occur and act like an atrial ectopy. However, the clinical significance of this phenomenon is not fully understood. We aimed to elucidate whether the clinical diagnosis of PVC can increase the risk of new-onset AF. We performed a nationwide population-based analysis using the Korean National Health Insurance Service database. A total of 9,537,713 people without prior history of PVC and AF were identified. Among these people, 4135 developed PVC in 2009, and people with and without PVC were followed until 2018. People who had PVC showed an increased risk of new-onset AF as compared with people without PVC (hazard ratio [HR] = 2.705; 95% confidence interval [CI] = 2.428–3.013; p < 0.001). The risk of ischemic stroke was also significantly increased in people with PVC (HR 1.160; 95% CI 1.048–1.284; p = 0.0041). New-onset AF developed in 72 people (19.3%) among 374 people with PVC who had ischemic stroke during their follow-up. A significant interaction was observed between PVC and age with people < 65 years at greater risk of new-onset AF for having PVC. In this observational analysis, the risk of new-onset AF and ischemic stroke was increased in people with PVC. Additional evaluation to identify AF in people with PVC can be helpful. Nature Publishing Group UK 2021-01-15 /pmc/articles/PMC7810887/ /pubmed/33452389 http://dx.doi.org/10.1038/s41598-021-81229-0 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kim, Yun Gi Han, Kyung-Do Choi, Jong-Il Choi, Yun Young Choi, Ha Young Shim, Jaemin Kim, Young-Hoon Premature ventricular contraction is associated with increased risk of atrial fibrillation: a nationwide population-based study |
title | Premature ventricular contraction is associated with increased risk of atrial fibrillation: a nationwide population-based study |
title_full | Premature ventricular contraction is associated with increased risk of atrial fibrillation: a nationwide population-based study |
title_fullStr | Premature ventricular contraction is associated with increased risk of atrial fibrillation: a nationwide population-based study |
title_full_unstemmed | Premature ventricular contraction is associated with increased risk of atrial fibrillation: a nationwide population-based study |
title_short | Premature ventricular contraction is associated with increased risk of atrial fibrillation: a nationwide population-based study |
title_sort | premature ventricular contraction is associated with increased risk of atrial fibrillation: a nationwide population-based study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810887/ https://www.ncbi.nlm.nih.gov/pubmed/33452389 http://dx.doi.org/10.1038/s41598-021-81229-0 |
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