Down‐regulation of EOMES drives T‐cell exhaustion via abolishing EOMES‐mediated repression of inhibitory receptors of T cells in liver cancer

T‐cell exhaustion is one of the hallmarks in cancer, but the mechanisms underlying T‐cell dysregulation remains unclear. Here, we reported that down‐regulation of transcription factor EOMES contributed to increased levels of inhibitory receptors in T cell among the tumour tissues and resulted in the...

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Detalles Bibliográficos
Autores principales: He, Hongwei, Yi, Yong, Cai, Xiaoyan, Wang, Jiaxing, Ni, Xiaochun, Fu, Yipeng, Qiu, Shuangjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810931/
https://www.ncbi.nlm.nih.gov/pubmed/33325636
http://dx.doi.org/10.1111/jcmm.15898

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