Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype

Therapy-induced senescence-associated secretory phenotype (SASP) correlates with overcoming resistance to immune checkpoint blockade (ICB). Intrinsic resistance to ICB is a major clinical challenge. For example, ovarian cancer is largely resistant to ICB. Here we show that adoptive transfer of SASP-...

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Detalles Bibliográficos
Autores principales: Hao, Xue, Zhao, Bo, Zhou, Wei, Liu, Heng, Fukumoto, Takeshi, Gabrilovich, Dmitry, Zhang, Rugang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811168/
https://www.ncbi.nlm.nih.gov/pubmed/33490922
http://dx.doi.org/10.1016/j.isci.2020.102016

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