Multiple-endpoint in vitro carcinogenicity test in human cell line TK6 distinguishes carcinogens from non-carcinogens and highlights mechanisms of action

Current in vitro genotoxicity tests can produce misleading positive results, indicating an inability to effectively predict a compound’s subsequent carcinogenic potential in vivo. Such oversensitivity can incur unnecessary in vivo tests to further investigate positive in vitro results, supporting th...

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Detalles Bibliográficos
Autores principales: Chapman, Katherine E., Wilde, Eleanor C., Chapman, Fiona M., Verma, Jatin R., Shah, Ume-Kulsoom, Stannard, Leanne M., Seager, Anna L., Tonkin, James A., Brown, M. Rowan, Doherty, Ann T., Johnson, George E., Doak, Shareen H., Jenkins, Gareth J. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Genotoxicity and Carcinogenicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811515/
https://www.ncbi.nlm.nih.gov/pubmed/32910239
http://dx.doi.org/10.1007/s00204-020-02902-3

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