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Novel testing strategy for prediction of rat biliary excretion of intravenously administered estradiol-17β glucuronide
The aim of the present study was to develop a generic rat physiologically based kinetic (PBK) model that includes a novel testing strategy where active biliary excretion is incorporated using estradiol-17β glucuronide (E(2)17βG) as the model substance. A major challenge was the definition of the sca...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811516/ https://www.ncbi.nlm.nih.gov/pubmed/33159584 http://dx.doi.org/10.1007/s00204-020-02908-x |