COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

Causes of mortality from COVID-19 include respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that recognizes pathogen-associated molecular patterns (PAMPs) including viral proteins and triggers the production of type I interferons...

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Detalles Bibliográficos
Autores principales: Aboudounya, Mohamed M., Heads, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811571/
https://www.ncbi.nlm.nih.gov/pubmed/33505220
http://dx.doi.org/10.1155/2021/8874339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811571/
https://www.ncbi.nlm.nih.gov/pubmed/33505220
http://dx.doi.org/10.1155/2021/8874339

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