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Anterior insula and inferior frontal gyrus: where ventral and dorsal visual attention systems meet
The clinical link between spatial and non-spatial attentional aspects in patients with hemispatial neglect is well known; in particular, an increase in alerting can transitorily help to allocate attention towards the contralesional side. In models of attention, this phenomenon is postulated to rely...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811755/ https://www.ncbi.nlm.nih.gov/pubmed/33501424 http://dx.doi.org/10.1093/braincomms/fcaa220 |
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author | Cazzoli, Dario Kaufmann, Brigitte C Paladini, Rebecca E Müri, René M Nef, Tobias Nyffeler, Thomas |
author_facet | Cazzoli, Dario Kaufmann, Brigitte C Paladini, Rebecca E Müri, René M Nef, Tobias Nyffeler, Thomas |
author_sort | Cazzoli, Dario |
collection | PubMed |
description | The clinical link between spatial and non-spatial attentional aspects in patients with hemispatial neglect is well known; in particular, an increase in alerting can transitorily help to allocate attention towards the contralesional side. In models of attention, this phenomenon is postulated to rely on an interaction between ventral and dorsal cortical networks, subtending non-spatial and spatial attentional aspects, respectively. However, the exact neural underpinnings of the interaction between these two networks are still poorly understood. In the present study, we included 80 right-hemispheric patients with subacute stroke (50% women; age range: 24–96), 33 with and 47 without neglect, as assessed by paper–pencil cancellation tests. The patients performed a computerized task in which they were asked to respond as quickly as possible by button-press to central targets, which were either preceded or not preceded by non-spatial, auditory warning tones. Reaction times in the two different conditions were measured. In neglect patients, a warning tone, enhancing activity within the ventral attentional ‘alerting’ network, could boost the reaction (in terms of shorter reaction times) of the dorsal attentional network to a visual stimulus up to the level of patients without neglect. Critically, using voxel-based lesion-symptom mapping analyses, we show that this effect significantly depends on the integrity of the right anterior insula and adjacent inferior frontal gyrus, i.e., right-hemispheric patients with lesions involving these areas were significantly less likely to show shorter reaction times when a warning tone was presented prior to visual target appearance. We propose that the right anterior insula and inferior frontal gyrus are a critical hub through which the ventral attentional network can ‘alert’ and increase the efficiency of the activity of the dorsal attentional network. |
format | Online Article Text |
id | pubmed-7811755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-78117552021-01-25 Anterior insula and inferior frontal gyrus: where ventral and dorsal visual attention systems meet Cazzoli, Dario Kaufmann, Brigitte C Paladini, Rebecca E Müri, René M Nef, Tobias Nyffeler, Thomas Brain Commun Original Article The clinical link between spatial and non-spatial attentional aspects in patients with hemispatial neglect is well known; in particular, an increase in alerting can transitorily help to allocate attention towards the contralesional side. In models of attention, this phenomenon is postulated to rely on an interaction between ventral and dorsal cortical networks, subtending non-spatial and spatial attentional aspects, respectively. However, the exact neural underpinnings of the interaction between these two networks are still poorly understood. In the present study, we included 80 right-hemispheric patients with subacute stroke (50% women; age range: 24–96), 33 with and 47 without neglect, as assessed by paper–pencil cancellation tests. The patients performed a computerized task in which they were asked to respond as quickly as possible by button-press to central targets, which were either preceded or not preceded by non-spatial, auditory warning tones. Reaction times in the two different conditions were measured. In neglect patients, a warning tone, enhancing activity within the ventral attentional ‘alerting’ network, could boost the reaction (in terms of shorter reaction times) of the dorsal attentional network to a visual stimulus up to the level of patients without neglect. Critically, using voxel-based lesion-symptom mapping analyses, we show that this effect significantly depends on the integrity of the right anterior insula and adjacent inferior frontal gyrus, i.e., right-hemispheric patients with lesions involving these areas were significantly less likely to show shorter reaction times when a warning tone was presented prior to visual target appearance. We propose that the right anterior insula and inferior frontal gyrus are a critical hub through which the ventral attentional network can ‘alert’ and increase the efficiency of the activity of the dorsal attentional network. Oxford University Press 2020-12-26 /pmc/articles/PMC7811755/ /pubmed/33501424 http://dx.doi.org/10.1093/braincomms/fcaa220 Text en © The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Article Cazzoli, Dario Kaufmann, Brigitte C Paladini, Rebecca E Müri, René M Nef, Tobias Nyffeler, Thomas Anterior insula and inferior frontal gyrus: where ventral and dorsal visual attention systems meet |
title | Anterior insula and inferior frontal gyrus: where ventral and dorsal visual attention systems meet |
title_full | Anterior insula and inferior frontal gyrus: where ventral and dorsal visual attention systems meet |
title_fullStr | Anterior insula and inferior frontal gyrus: where ventral and dorsal visual attention systems meet |
title_full_unstemmed | Anterior insula and inferior frontal gyrus: where ventral and dorsal visual attention systems meet |
title_short | Anterior insula and inferior frontal gyrus: where ventral and dorsal visual attention systems meet |
title_sort | anterior insula and inferior frontal gyrus: where ventral and dorsal visual attention systems meet |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811755/ https://www.ncbi.nlm.nih.gov/pubmed/33501424 http://dx.doi.org/10.1093/braincomms/fcaa220 |
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