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The effect of alpha-2 adrenergic receptors on memory retention deficit induced by rapid eye movement sleep deprivation
OBJECTIVE(S): Evidence shows that sleep deprivation (SD) disrupts the formation of hippocampus-related memories. Moreover, α2 adrenergic receptors that are wildly expressed in the CA1 hippocampal region have a significant role in modulating both sleep and memory formation. In the present research, w...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mashhad University of Medical Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811809/ https://www.ncbi.nlm.nih.gov/pubmed/33489031 http://dx.doi.org/10.22038/ijbms.2020.44891.10468 |
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author | Norozpour, Yaser Nasehi, Mohammad Sabouri-Khanghah, Vahid Nami, Mohammad Vaseghi, Salar Zarrindast, Mohammad-Reza |
author_facet | Norozpour, Yaser Nasehi, Mohammad Sabouri-Khanghah, Vahid Nami, Mohammad Vaseghi, Salar Zarrindast, Mohammad-Reza |
author_sort | Norozpour, Yaser |
collection | PubMed |
description | OBJECTIVE(S): Evidence shows that sleep deprivation (SD) disrupts the formation of hippocampus-related memories. Moreover, α2 adrenergic receptors that are wildly expressed in the CA1 hippocampal region have a significant role in modulating both sleep and memory formation. In the present research, we wanted to investigate the effect of stimulation and blockage of CA1 α2 adrenergic receptors by clonidine (an agonist of α2 adrenergic receptor) and yohimbine (an antagonist of α2 adrenergic receptor), respectively, on memory retention impairment induced by REM SD (RSD) in rats. MATERIALS AND METHODS: Multiple platform apparatus were used to induce RSD, and the passive avoidance task was used to assess memory consolidation. Clonidine and yohimbine were injected intra-CA1. RESULTS: The results showed that RSD (for 24 and 36, but not 12 hr) decreased memory retention, with no effect on locomotion. Post-training intra-CA1 infusion of a subthreshold dose of yohimbine (0.001 μg/rat) did not alter, while clonidine (0.1 μg/rat) restored memory retention impairment induced by RSD (24 and 36 hr). Also, none of the interventions did not influence locomotor activity. CONCLUSION: Our data strongly showed that CA1 α2 adrenergic receptors have a critical role in RSD-induced memory retention impairment. |
format | Online Article Text |
id | pubmed-7811809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Mashhad University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-78118092021-01-22 The effect of alpha-2 adrenergic receptors on memory retention deficit induced by rapid eye movement sleep deprivation Norozpour, Yaser Nasehi, Mohammad Sabouri-Khanghah, Vahid Nami, Mohammad Vaseghi, Salar Zarrindast, Mohammad-Reza Iran J Basic Med Sci Original Article OBJECTIVE(S): Evidence shows that sleep deprivation (SD) disrupts the formation of hippocampus-related memories. Moreover, α2 adrenergic receptors that are wildly expressed in the CA1 hippocampal region have a significant role in modulating both sleep and memory formation. In the present research, we wanted to investigate the effect of stimulation and blockage of CA1 α2 adrenergic receptors by clonidine (an agonist of α2 adrenergic receptor) and yohimbine (an antagonist of α2 adrenergic receptor), respectively, on memory retention impairment induced by REM SD (RSD) in rats. MATERIALS AND METHODS: Multiple platform apparatus were used to induce RSD, and the passive avoidance task was used to assess memory consolidation. Clonidine and yohimbine were injected intra-CA1. RESULTS: The results showed that RSD (for 24 and 36, but not 12 hr) decreased memory retention, with no effect on locomotion. Post-training intra-CA1 infusion of a subthreshold dose of yohimbine (0.001 μg/rat) did not alter, while clonidine (0.1 μg/rat) restored memory retention impairment induced by RSD (24 and 36 hr). Also, none of the interventions did not influence locomotor activity. CONCLUSION: Our data strongly showed that CA1 α2 adrenergic receptors have a critical role in RSD-induced memory retention impairment. Mashhad University of Medical Sciences 2020-12 /pmc/articles/PMC7811809/ /pubmed/33489031 http://dx.doi.org/10.22038/ijbms.2020.44891.10468 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Norozpour, Yaser Nasehi, Mohammad Sabouri-Khanghah, Vahid Nami, Mohammad Vaseghi, Salar Zarrindast, Mohammad-Reza The effect of alpha-2 adrenergic receptors on memory retention deficit induced by rapid eye movement sleep deprivation |
title | The effect of alpha-2 adrenergic receptors on memory retention deficit induced by rapid eye movement sleep deprivation |
title_full | The effect of alpha-2 adrenergic receptors on memory retention deficit induced by rapid eye movement sleep deprivation |
title_fullStr | The effect of alpha-2 adrenergic receptors on memory retention deficit induced by rapid eye movement sleep deprivation |
title_full_unstemmed | The effect of alpha-2 adrenergic receptors on memory retention deficit induced by rapid eye movement sleep deprivation |
title_short | The effect of alpha-2 adrenergic receptors on memory retention deficit induced by rapid eye movement sleep deprivation |
title_sort | effect of alpha-2 adrenergic receptors on memory retention deficit induced by rapid eye movement sleep deprivation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811809/ https://www.ncbi.nlm.nih.gov/pubmed/33489031 http://dx.doi.org/10.22038/ijbms.2020.44891.10468 |
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