Cargando…

Evaluation and Comparison of Predictive Value of Tumor Regression Grades according to Mandard and Becker in Locally Advanced Gastric Adenocarcinoma

PURPOSE: Tumor regression grade (TRG) has been widely used in gastrointestinal carcinoma to assess pathological responses to neoadjuvant chemotherapy (NCT). There are various standards without a consensus, and it is still unclear which kind of system has better predictive value. This study aims to i...

Descripción completa

Detalles Bibliográficos
Autores principales: Tong, Yilin, Zhu, Yanmei, Zhao, Yan, Shan, Zexing, Liu, Dong, Zhang, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812022/
https://www.ncbi.nlm.nih.gov/pubmed/32777876
http://dx.doi.org/10.4143/crt.2020.516
_version_ 1783637579584765952
author Tong, Yilin
Zhu, Yanmei
Zhao, Yan
Shan, Zexing
Liu, Dong
Zhang, Jianjun
author_facet Tong, Yilin
Zhu, Yanmei
Zhao, Yan
Shan, Zexing
Liu, Dong
Zhang, Jianjun
author_sort Tong, Yilin
collection PubMed
description PURPOSE: Tumor regression grade (TRG) has been widely used in gastrointestinal carcinoma to assess pathological responses to neoadjuvant chemotherapy (NCT). There are various standards without a consensus, and it is still unclear which kind of system has better predictive value. This study aims to investigate and compare the predictive ability of the Mandard and Becker TRGs in patients with locally advanced gastric cancer. MATERIALS AND METHODS: A total of 290 patients with locally advanced gastric adenocarcinoma who underwent NCT and curative surgery were studied. Survival analysis for overall survival (OS) and disease-free survival (DFS) were based on the Kaplan-Meier method and Cox proportional hazards method. Predictive values of TRGs and models were assessed by time-dependent receiver operating characteristic (ROC) curve, the area under the ROC curve (AUC), nomogram, and calibration curve. RESULTS: In multivariable analysis, the Mandard TRG was associated with OS (hazard ratio [HR], 1.806; p=0.026) and DFS (HR, 1.792; p=0.017). The Becker TRG was also related to OS (HR, 1.880; p=0.014) and DFS (HR, 1.919; p=0.006). The Mandard and Becker TRG AUCs for 5-year survival were 0.72 and 0.71, respectively. The whole models showed an increased predictive value, with AUCs of 0.85 and 0.86, respectively. There was no significant difference between the two TRGs and two models. CONCLUSION: TRG was an independent predictor for survival, and there was no significant difference between these two systems.
format Online
Article
Text
id pubmed-7812022
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Korean Cancer Association
record_format MEDLINE/PubMed
spelling pubmed-78120222021-01-26 Evaluation and Comparison of Predictive Value of Tumor Regression Grades according to Mandard and Becker in Locally Advanced Gastric Adenocarcinoma Tong, Yilin Zhu, Yanmei Zhao, Yan Shan, Zexing Liu, Dong Zhang, Jianjun Cancer Res Treat Original Article PURPOSE: Tumor regression grade (TRG) has been widely used in gastrointestinal carcinoma to assess pathological responses to neoadjuvant chemotherapy (NCT). There are various standards without a consensus, and it is still unclear which kind of system has better predictive value. This study aims to investigate and compare the predictive ability of the Mandard and Becker TRGs in patients with locally advanced gastric cancer. MATERIALS AND METHODS: A total of 290 patients with locally advanced gastric adenocarcinoma who underwent NCT and curative surgery were studied. Survival analysis for overall survival (OS) and disease-free survival (DFS) were based on the Kaplan-Meier method and Cox proportional hazards method. Predictive values of TRGs and models were assessed by time-dependent receiver operating characteristic (ROC) curve, the area under the ROC curve (AUC), nomogram, and calibration curve. RESULTS: In multivariable analysis, the Mandard TRG was associated with OS (hazard ratio [HR], 1.806; p=0.026) and DFS (HR, 1.792; p=0.017). The Becker TRG was also related to OS (HR, 1.880; p=0.014) and DFS (HR, 1.919; p=0.006). The Mandard and Becker TRG AUCs for 5-year survival were 0.72 and 0.71, respectively. The whole models showed an increased predictive value, with AUCs of 0.85 and 0.86, respectively. There was no significant difference between the two TRGs and two models. CONCLUSION: TRG was an independent predictor for survival, and there was no significant difference between these two systems. Korean Cancer Association 2021-01 2020-08-10 /pmc/articles/PMC7812022/ /pubmed/32777876 http://dx.doi.org/10.4143/crt.2020.516 Text en Copyright © 2021 by the Korean Cancer Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Tong, Yilin
Zhu, Yanmei
Zhao, Yan
Shan, Zexing
Liu, Dong
Zhang, Jianjun
Evaluation and Comparison of Predictive Value of Tumor Regression Grades according to Mandard and Becker in Locally Advanced Gastric Adenocarcinoma
title Evaluation and Comparison of Predictive Value of Tumor Regression Grades according to Mandard and Becker in Locally Advanced Gastric Adenocarcinoma
title_full Evaluation and Comparison of Predictive Value of Tumor Regression Grades according to Mandard and Becker in Locally Advanced Gastric Adenocarcinoma
title_fullStr Evaluation and Comparison of Predictive Value of Tumor Regression Grades according to Mandard and Becker in Locally Advanced Gastric Adenocarcinoma
title_full_unstemmed Evaluation and Comparison of Predictive Value of Tumor Regression Grades according to Mandard and Becker in Locally Advanced Gastric Adenocarcinoma
title_short Evaluation and Comparison of Predictive Value of Tumor Regression Grades according to Mandard and Becker in Locally Advanced Gastric Adenocarcinoma
title_sort evaluation and comparison of predictive value of tumor regression grades according to mandard and becker in locally advanced gastric adenocarcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812022/
https://www.ncbi.nlm.nih.gov/pubmed/32777876
http://dx.doi.org/10.4143/crt.2020.516
work_keys_str_mv AT tongyilin evaluationandcomparisonofpredictivevalueoftumorregressiongradesaccordingtomandardandbeckerinlocallyadvancedgastricadenocarcinoma
AT zhuyanmei evaluationandcomparisonofpredictivevalueoftumorregressiongradesaccordingtomandardandbeckerinlocallyadvancedgastricadenocarcinoma
AT zhaoyan evaluationandcomparisonofpredictivevalueoftumorregressiongradesaccordingtomandardandbeckerinlocallyadvancedgastricadenocarcinoma
AT shanzexing evaluationandcomparisonofpredictivevalueoftumorregressiongradesaccordingtomandardandbeckerinlocallyadvancedgastricadenocarcinoma
AT liudong evaluationandcomparisonofpredictivevalueoftumorregressiongradesaccordingtomandardandbeckerinlocallyadvancedgastricadenocarcinoma
AT zhangjianjun evaluationandcomparisonofpredictivevalueoftumorregressiongradesaccordingtomandardandbeckerinlocallyadvancedgastricadenocarcinoma