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Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions
Pharmacogenomics has been used effectively in studying adverse drug reactions by determining the person-specific genetic factors associated with individual response to a drug. Current approaches have revealed the significant importance of sequencing technologies and sequence analysis strategies for...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812041/ https://www.ncbi.nlm.nih.gov/pubmed/33469342 http://dx.doi.org/10.2147/PGPM.S290781 |
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author | Tong, Hang Phan, Nga V T Nguyen, Thanh T Nguyen, Dinh V Vo, Nam S Le, Ly |
author_facet | Tong, Hang Phan, Nga V T Nguyen, Thanh T Nguyen, Dinh V Vo, Nam S Le, Ly |
author_sort | Tong, Hang |
collection | PubMed |
description | Pharmacogenomics has been used effectively in studying adverse drug reactions by determining the person-specific genetic factors associated with individual response to a drug. Current approaches have revealed the significant importance of sequencing technologies and sequence analysis strategies for interpreting the contribution of genetic variation in developing adverse reactions. Advance in next generation sequencing and platform brings new opportunities in validating the genetic candidates in certain reactions, and could be used to develop the preemptive tests to predict the outcome of the variation in a personal response to a drug. With the highly accumulated available data recently, the in silico approach with data analysis and modeling plays as other important alternatives which significantly support the final decisions in the transformation from research to clinical applications such as diagnosis and treatments for various types of adverse responses. |
format | Online Article Text |
id | pubmed-7812041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-78120412021-01-18 Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions Tong, Hang Phan, Nga V T Nguyen, Thanh T Nguyen, Dinh V Vo, Nam S Le, Ly Pharmgenomics Pers Med Review Pharmacogenomics has been used effectively in studying adverse drug reactions by determining the person-specific genetic factors associated with individual response to a drug. Current approaches have revealed the significant importance of sequencing technologies and sequence analysis strategies for interpreting the contribution of genetic variation in developing adverse reactions. Advance in next generation sequencing and platform brings new opportunities in validating the genetic candidates in certain reactions, and could be used to develop the preemptive tests to predict the outcome of the variation in a personal response to a drug. With the highly accumulated available data recently, the in silico approach with data analysis and modeling plays as other important alternatives which significantly support the final decisions in the transformation from research to clinical applications such as diagnosis and treatments for various types of adverse responses. Dove 2021-01-13 /pmc/articles/PMC7812041/ /pubmed/33469342 http://dx.doi.org/10.2147/PGPM.S290781 Text en © 2021 Tong et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Tong, Hang Phan, Nga V T Nguyen, Thanh T Nguyen, Dinh V Vo, Nam S Le, Ly Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions |
title | Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions |
title_full | Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions |
title_fullStr | Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions |
title_full_unstemmed | Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions |
title_short | Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions |
title_sort | review on databases and bioinformatic approaches on pharmacogenomics of adverse drug reactions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812041/ https://www.ncbi.nlm.nih.gov/pubmed/33469342 http://dx.doi.org/10.2147/PGPM.S290781 |
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