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Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions

Pharmacogenomics has been used effectively in studying adverse drug reactions by determining the person-specific genetic factors associated with individual response to a drug. Current approaches have revealed the significant importance of sequencing technologies and sequence analysis strategies for...

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Autores principales: Tong, Hang, Phan, Nga V T, Nguyen, Thanh T, Nguyen, Dinh V, Vo, Nam S, Le, Ly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812041/
https://www.ncbi.nlm.nih.gov/pubmed/33469342
http://dx.doi.org/10.2147/PGPM.S290781
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author Tong, Hang
Phan, Nga V T
Nguyen, Thanh T
Nguyen, Dinh V
Vo, Nam S
Le, Ly
author_facet Tong, Hang
Phan, Nga V T
Nguyen, Thanh T
Nguyen, Dinh V
Vo, Nam S
Le, Ly
author_sort Tong, Hang
collection PubMed
description Pharmacogenomics has been used effectively in studying adverse drug reactions by determining the person-specific genetic factors associated with individual response to a drug. Current approaches have revealed the significant importance of sequencing technologies and sequence analysis strategies for interpreting the contribution of genetic variation in developing adverse reactions. Advance in next generation sequencing and platform brings new opportunities in validating the genetic candidates in certain reactions, and could be used to develop the preemptive tests to predict the outcome of the variation in a personal response to a drug. With the highly accumulated available data recently, the in silico approach with data analysis and modeling plays as other important alternatives which significantly support the final decisions in the transformation from research to clinical applications such as diagnosis and treatments for various types of adverse responses.
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spelling pubmed-78120412021-01-18 Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions Tong, Hang Phan, Nga V T Nguyen, Thanh T Nguyen, Dinh V Vo, Nam S Le, Ly Pharmgenomics Pers Med Review Pharmacogenomics has been used effectively in studying adverse drug reactions by determining the person-specific genetic factors associated with individual response to a drug. Current approaches have revealed the significant importance of sequencing technologies and sequence analysis strategies for interpreting the contribution of genetic variation in developing adverse reactions. Advance in next generation sequencing and platform brings new opportunities in validating the genetic candidates in certain reactions, and could be used to develop the preemptive tests to predict the outcome of the variation in a personal response to a drug. With the highly accumulated available data recently, the in silico approach with data analysis and modeling plays as other important alternatives which significantly support the final decisions in the transformation from research to clinical applications such as diagnosis and treatments for various types of adverse responses. Dove 2021-01-13 /pmc/articles/PMC7812041/ /pubmed/33469342 http://dx.doi.org/10.2147/PGPM.S290781 Text en © 2021 Tong et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Tong, Hang
Phan, Nga V T
Nguyen, Thanh T
Nguyen, Dinh V
Vo, Nam S
Le, Ly
Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions
title Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions
title_full Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions
title_fullStr Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions
title_full_unstemmed Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions
title_short Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions
title_sort review on databases and bioinformatic approaches on pharmacogenomics of adverse drug reactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812041/
https://www.ncbi.nlm.nih.gov/pubmed/33469342
http://dx.doi.org/10.2147/PGPM.S290781
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