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Antidepressant use and interpersonal violence perpetration: a protocol for a systematic review and meta-analysis
INTRODUCTION: There are conflicting perspectives as to whether antidepressant medication increases, decreases or has no effect on violence perpetration, impulsivity and aggressive behaviour. This is an important question given the widespread use of antidepressant medication and the significant medic...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812107/ https://www.ncbi.nlm.nih.gov/pubmed/33441364 http://dx.doi.org/10.1136/bmjopen-2020-043306 |
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author | Keen, Claire Foulds, James A Willoughby, Melissa Newton-Howes, Giles Knight, Josh Fazel, Seena Borschmann, Rohan Kinner, Stuart A Young, Jesse T |
author_facet | Keen, Claire Foulds, James A Willoughby, Melissa Newton-Howes, Giles Knight, Josh Fazel, Seena Borschmann, Rohan Kinner, Stuart A Young, Jesse T |
author_sort | Keen, Claire |
collection | PubMed |
description | INTRODUCTION: There are conflicting perspectives as to whether antidepressant medication increases, decreases or has no effect on violence perpetration, impulsivity and aggressive behaviour. This is an important question given the widespread use of antidepressant medication and the significant medical, social, legal and health consequences of violence. We aim to: (1) systematically identify observational studies and randomised controlled trials that quantify the relationship between antidepressant use and interpersonal violence; (2) assess the quality of studies that quantify the relationship between antidepressant use and interpersonal violence and (3) estimate the pooled prevalence and measure of effect for the relationship between antidepressant use and interpersonal violence. METHODS AND ANALYSIS: We will search MEDLINE, EMBASE, CINAHL, PsycINFO, PubMed and the Cochrane Library for relevant peer-reviewed literature. Our primary outcome is the perpetration of violent acts directed at others. Our secondary outcome is physical, interpersonal aggression measured through validated surveys. We will include randomised controlled trials, cohort studies and case–control studies that examine the association between the use of antidepressants and violence perpetration and/or physical aggression. No restrictions will be placed on the population. We will use the Methodological Standard for Epidemiological Research scale to assess the quality of included studies. We will provide an overview of the included studies and assess heterogeneity and publication bias. If there are sufficient studies, we will conduct meta-analyses to examine the possible association between antidepressants and violence, and undertake meta-regression to examine the effect of antidepressant class, length of follow-up, age of participants and population subgroups on the association between antidepressants and violence. ETHICS AND DISSEMINATION: No ethics approval is required. Our findings will be disseminated through a peer-reviewed journal article and conference presentations. PROSPERO REGISTRATION DETAILS: CRD42020175474. |
format | Online Article Text |
id | pubmed-7812107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-78121072021-01-25 Antidepressant use and interpersonal violence perpetration: a protocol for a systematic review and meta-analysis Keen, Claire Foulds, James A Willoughby, Melissa Newton-Howes, Giles Knight, Josh Fazel, Seena Borschmann, Rohan Kinner, Stuart A Young, Jesse T BMJ Open Public Health INTRODUCTION: There are conflicting perspectives as to whether antidepressant medication increases, decreases or has no effect on violence perpetration, impulsivity and aggressive behaviour. This is an important question given the widespread use of antidepressant medication and the significant medical, social, legal and health consequences of violence. We aim to: (1) systematically identify observational studies and randomised controlled trials that quantify the relationship between antidepressant use and interpersonal violence; (2) assess the quality of studies that quantify the relationship between antidepressant use and interpersonal violence and (3) estimate the pooled prevalence and measure of effect for the relationship between antidepressant use and interpersonal violence. METHODS AND ANALYSIS: We will search MEDLINE, EMBASE, CINAHL, PsycINFO, PubMed and the Cochrane Library for relevant peer-reviewed literature. Our primary outcome is the perpetration of violent acts directed at others. Our secondary outcome is physical, interpersonal aggression measured through validated surveys. We will include randomised controlled trials, cohort studies and case–control studies that examine the association between the use of antidepressants and violence perpetration and/or physical aggression. No restrictions will be placed on the population. We will use the Methodological Standard for Epidemiological Research scale to assess the quality of included studies. We will provide an overview of the included studies and assess heterogeneity and publication bias. If there are sufficient studies, we will conduct meta-analyses to examine the possible association between antidepressants and violence, and undertake meta-regression to examine the effect of antidepressant class, length of follow-up, age of participants and population subgroups on the association between antidepressants and violence. ETHICS AND DISSEMINATION: No ethics approval is required. Our findings will be disseminated through a peer-reviewed journal article and conference presentations. PROSPERO REGISTRATION DETAILS: CRD42020175474. BMJ Publishing Group 2021-01-13 /pmc/articles/PMC7812107/ /pubmed/33441364 http://dx.doi.org/10.1136/bmjopen-2020-043306 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Public Health Keen, Claire Foulds, James A Willoughby, Melissa Newton-Howes, Giles Knight, Josh Fazel, Seena Borschmann, Rohan Kinner, Stuart A Young, Jesse T Antidepressant use and interpersonal violence perpetration: a protocol for a systematic review and meta-analysis |
title | Antidepressant use and interpersonal violence perpetration: a protocol for a systematic review and meta-analysis |
title_full | Antidepressant use and interpersonal violence perpetration: a protocol for a systematic review and meta-analysis |
title_fullStr | Antidepressant use and interpersonal violence perpetration: a protocol for a systematic review and meta-analysis |
title_full_unstemmed | Antidepressant use and interpersonal violence perpetration: a protocol for a systematic review and meta-analysis |
title_short | Antidepressant use and interpersonal violence perpetration: a protocol for a systematic review and meta-analysis |
title_sort | antidepressant use and interpersonal violence perpetration: a protocol for a systematic review and meta-analysis |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812107/ https://www.ncbi.nlm.nih.gov/pubmed/33441364 http://dx.doi.org/10.1136/bmjopen-2020-043306 |
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