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Clinical features, prognosis, and influencing factors of contralateral prophylactic mastectomy in 58 patients with breast cancer

BACKGROUND: The past two decades have witnessed the increasing application of contralateral prophylactic mastectomy (CPM) for women with breast cancer in the western countries. Over 30% of young patients choose to underwent CPM up to 2015. However, the adoption rate of CPM has not shown a remarkably...

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Autores principales: Zheng, Yiqiong, Li, Jie, Hong, Chenyan, Wu, Huan, Lige, Wuri, Qi, Aiying, Guo, Jin, Wang, Jiandong, Zhu, Li, Li, Xiru, Zhang, Yanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812232/
https://www.ncbi.nlm.nih.gov/pubmed/33490177
http://dx.doi.org/10.21037/atm-20-7780
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author Zheng, Yiqiong
Li, Jie
Hong, Chenyan
Wu, Huan
Lige, Wuri
Qi, Aiying
Guo, Jin
Wang, Jiandong
Zhu, Li
Li, Xiru
Zhang, Yanjun
author_facet Zheng, Yiqiong
Li, Jie
Hong, Chenyan
Wu, Huan
Lige, Wuri
Qi, Aiying
Guo, Jin
Wang, Jiandong
Zhu, Li
Li, Xiru
Zhang, Yanjun
author_sort Zheng, Yiqiong
collection PubMed
description BACKGROUND: The past two decades have witnessed the increasing application of contralateral prophylactic mastectomy (CPM) for women with breast cancer in the western countries. Over 30% of young patients choose to underwent CPM up to 2015. However, the adoption rate of CPM has not shown a remarkably increasing in Asian countries. In China, only a few centers have introduced CPM, and no relevant literature has been published. In this study, we look forward to identify the clinical features and prognostic factors of women who underwent CPM in our hospital, to inform decision-making processes for both doctors and patients. METHODS: The clinical data of 58 eligible patients were retrospectively analyzed. Intergroup comparisons were based on independent samples t-test and chi square test. The 5-year disease-free survival (DFS) and overall survival (OS) were obtained by using life tables, and factors affecting the survivals were analyzed by using the Kaplan-Meier method. RESULTS: The mean age of these women was 40.14±11.17 years, with 30 patients (51.7%) being ≤40 years; 13 patients (22.4%) had a family history of breast cancer; and 49 (69.0%) had known risk factors for breast cancer. The median follow-up period was 66.77 months, the 5-year OS was 89% and the 5-year DFS was 74%. The average age of onset was 41.53 (±10.964) in the disease-free survival group and 34.18 (±10.4) years in the recurrence/metastasis group, and t-test revealed a significant difference in the average age between these two groups (P=0.049). Chi-square test showed that the disease progression rate significantly differed among the different age subgroups and among subjects with different body mass index (BMI) (all P≤0.05). Moreover, surgical procedure, family history of breast cancer, and some other factors showed no significant correlation with disease progression (all P>0.05). Kaplan-Meier survival analysis and log rank test further confirmed the above findings. CONCLUSIONS: The majority of patients who choose CPM are young and with known risk factors for breast cancer. Part of the young patients (≤40 years of age) are at a higher risk of disease progression.
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spelling pubmed-78122322021-01-22 Clinical features, prognosis, and influencing factors of contralateral prophylactic mastectomy in 58 patients with breast cancer Zheng, Yiqiong Li, Jie Hong, Chenyan Wu, Huan Lige, Wuri Qi, Aiying Guo, Jin Wang, Jiandong Zhu, Li Li, Xiru Zhang, Yanjun Ann Transl Med Original Article BACKGROUND: The past two decades have witnessed the increasing application of contralateral prophylactic mastectomy (CPM) for women with breast cancer in the western countries. Over 30% of young patients choose to underwent CPM up to 2015. However, the adoption rate of CPM has not shown a remarkably increasing in Asian countries. In China, only a few centers have introduced CPM, and no relevant literature has been published. In this study, we look forward to identify the clinical features and prognostic factors of women who underwent CPM in our hospital, to inform decision-making processes for both doctors and patients. METHODS: The clinical data of 58 eligible patients were retrospectively analyzed. Intergroup comparisons were based on independent samples t-test and chi square test. The 5-year disease-free survival (DFS) and overall survival (OS) were obtained by using life tables, and factors affecting the survivals were analyzed by using the Kaplan-Meier method. RESULTS: The mean age of these women was 40.14±11.17 years, with 30 patients (51.7%) being ≤40 years; 13 patients (22.4%) had a family history of breast cancer; and 49 (69.0%) had known risk factors for breast cancer. The median follow-up period was 66.77 months, the 5-year OS was 89% and the 5-year DFS was 74%. The average age of onset was 41.53 (±10.964) in the disease-free survival group and 34.18 (±10.4) years in the recurrence/metastasis group, and t-test revealed a significant difference in the average age between these two groups (P=0.049). Chi-square test showed that the disease progression rate significantly differed among the different age subgroups and among subjects with different body mass index (BMI) (all P≤0.05). Moreover, surgical procedure, family history of breast cancer, and some other factors showed no significant correlation with disease progression (all P>0.05). Kaplan-Meier survival analysis and log rank test further confirmed the above findings. CONCLUSIONS: The majority of patients who choose CPM are young and with known risk factors for breast cancer. Part of the young patients (≤40 years of age) are at a higher risk of disease progression. AME Publishing Company 2020-12 /pmc/articles/PMC7812232/ /pubmed/33490177 http://dx.doi.org/10.21037/atm-20-7780 Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Zheng, Yiqiong
Li, Jie
Hong, Chenyan
Wu, Huan
Lige, Wuri
Qi, Aiying
Guo, Jin
Wang, Jiandong
Zhu, Li
Li, Xiru
Zhang, Yanjun
Clinical features, prognosis, and influencing factors of contralateral prophylactic mastectomy in 58 patients with breast cancer
title Clinical features, prognosis, and influencing factors of contralateral prophylactic mastectomy in 58 patients with breast cancer
title_full Clinical features, prognosis, and influencing factors of contralateral prophylactic mastectomy in 58 patients with breast cancer
title_fullStr Clinical features, prognosis, and influencing factors of contralateral prophylactic mastectomy in 58 patients with breast cancer
title_full_unstemmed Clinical features, prognosis, and influencing factors of contralateral prophylactic mastectomy in 58 patients with breast cancer
title_short Clinical features, prognosis, and influencing factors of contralateral prophylactic mastectomy in 58 patients with breast cancer
title_sort clinical features, prognosis, and influencing factors of contralateral prophylactic mastectomy in 58 patients with breast cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812232/
https://www.ncbi.nlm.nih.gov/pubmed/33490177
http://dx.doi.org/10.21037/atm-20-7780
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