Cargando…

Extracellular vesicles from skin precursor-derived Schwann cells promote axonal outgrowth and regeneration of motoneurons via Akt/mTOR/p70S6K pathway

BACKGROUND: Skin precursor-derived Schwann cells (SKP-SCs) have been shown to benefit the recovery of spinal cord injury (SCI) and peripheral nerve injury (PNI) with motor dysfunction. However, the effect of extracellular vesicles (EVs) from SKP-SCs responsible for neuroregeneration remains unknown....

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Xia, Wang, Liting, Cong, Meng, Shen, Mi, He, Qianru, Ding, Fei, Shi, Haiyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812244/ https://www.ncbi.nlm.nih.gov/pubmed/33490152 http://dx.doi.org/10.21037/atm-20-5965

Ejemplares similares

Rgs4 is a regulator of mTOR activity required for motoneuron axon outgrowth and neuronal development in zebrafish
por: Mikdache, Aya, et al.
Publicado: (2021)

c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling
por: Fontana, Xavier, et al.
Publicado: (2012)

Neuroligin 3 Regulates Dendritic Outgrowth by Modulating Akt/mTOR Signaling
por: Xu, Jing, et al.
Publicado: (2019)

Ginkgo biloba extract increases neurite outgrowth and activates the Akt/mTOR pathway
por: Lejri, Imane, et al.
Publicado: (2019)

Improvement of sensory neuron growth and survival via negatively regulating PTEN by miR-21-5p-contained small extracellular vesicles from skin precursor-derived Schwann cells
por: Cong, Meng, et al.
Publicado: (2021)

Immunoglobulins stimulate cultured Schwann cell maturation and promote their potential to induce axonal outgrowth
por: Tzekova, Nevena, et al.
Publicado: (2015)

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Regulates Neurite Outgrowth Through the Activation of Akt/mTOR and Erk/mTOR Signaling Pathways
por: Wen, Wen, et al.
Publicado: (2020)

Mitochondrial Damage-Associated Molecular Patterns of Injured Axons Induce Outgrowth of Schwann Cell Processes
por: Korimová, Andrea, et al.
Publicado: (2018)

Cytoskeletal assembly in axonal outgrowth and regeneration analyzed on the nanoscale
por: Hofmann, Max, et al.
Publicado: (2022)

Proper migration and axon outgrowth of zebrafish cranial motoneuron subpopulations require the cell adhesion molecule MDGA2A
por: Ingold, Esther, et al.
Publicado: (2015)

Changes in the amounts of cytoskeletal proteins within the perikarya and axons of regenerating frog motoneurons
Publicado: (1983)

PTEN modulates neurites outgrowth and neuron apoptosis involving the PI3K/Akt/mTOR signaling pathway
por: Liu, Shen, et al.
Publicado: (2019)

Knockdown of Amyloid Precursor Protein in Zebrafish Causes Defects in Motor Axon Outgrowth
por: Song, Ping, et al.
Publicado: (2012)

Matrilin-2 within a three-dimensional lysine-modified chitosan porous scaffold enhances Schwann cell migration and axonal outgrowth for peripheral nerve regeneration
por: Li, Neill Y., et al.
Publicado: (2023)

A Review on the Role of Endogenous Neurotrophins and Schwann Cells in Axonal Regeneration
por: Pandey, Samyak, et al.
Publicado: (2021)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion
por: Chen, Weitao, et al.
Publicado: (2017)

Axon-Schwann cell interactions during peripheral nerve regeneration in zebrafish larvae
por: Ceci, Maria Laura, et al.
Publicado: (2014)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Fibronectin supports neurite outgrowth and axonal regeneration of adult brain neurons in vitro
por: Tonge, David A., et al.
Publicado: (2012)

UBTOR/KIAA1024 regulates neurite outgrowth and neoplasia through mTOR signaling
por: Zhang, Hefei, et al.
Publicado: (2018)

Betacellulin regulates peripheral nerve regeneration by affecting Schwann cell migration and axon elongation
por: Wang, Yaxian, et al.
Publicado: (2021)

Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury
por: Endo, Takeshi, et al.
Publicado: (2022)

Human milk extracellular vesicles enhance muscle growth and physical performance of immature mice associating with Akt/mTOR/p70s6k signaling pathway
por: Meng, Zitong, et al.
Publicado: (2023)

Roles of mTOR Signaling in Tissue Regeneration
por: Wei, Xiangyong, et al.
Publicado: (2019)

Spinal root avulsion: an excellent model for studying motoneuron degeneration and regeneration after severe axonal injury
por: Ruven, Carolin, et al.
Publicado: (2014)

Aucubin Promotes Neurite Outgrowth in Neural Stem Cells and Axonal Regeneration in Sciatic Nerves
por: Kim, Yong Min, et al.
Publicado: (2014)

AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines
por: Leal, Pamela, et al.
Publicado: (2013)

The Role of inab in Axon Morphology of an Identified Zebrafish Motoneuron
por: Van Ryswyk, Liesl, et al.
Publicado: (2014)

Axon initial segment geometry in relation to motoneuron excitability
por: Rotterman, Travis M., et al.
Publicado: (2021)

Exosomes derived from miR-26a-modified MSCs promote axonal regeneration via the PTEN/AKT/mTOR pathway following spinal cord injury
por: Chen, Yuyong, et al.
Publicado: (2021)

Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury
por: Pot, Caroline, et al.
Publicado: (2002)

Laminin γ1 is critical for Schwann cell differentiation, axon myelination, and regeneration in the peripheral nerve
por: Chen, Zu-Lin, et al.
Publicado: (2003)

Analysis of Schwann Cell Migration and Axon Regeneration Following Nerve Injury in the Sciatic Nerve Bridge
por: Chen, Bing, et al.
Publicado: (2019)

Reactivation of Denervated Schwann Cells by Embryonic Spinal Cord Neurons to Promote Axon Regeneration and Remyelination
por: Fang, Xinyu, et al.
Publicado: (2019)

Upregulated lncARAT in Schwann cells promotes axonal regeneration by recruiting and activating proregenerative macrophages
por: Yin, Gang, et al.
Publicado: (2022)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

Akt and mTOR mediate programmed necrosis in neurons
por: Liu, Q, et al.
Publicado: (2014)

The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer
por: Trinh, X B, et al.
Publicado: (2009)

Carnosine Inhibits the Proliferation of Human Gastric Carcinoma Cells by Retarding Akt/mTOR/p70S6K Signaling
por: Zhang, Zhenwei, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_31q53ph8667qb7dsfpv2pma2qr