Cargando…

Gracillin shows potent efficacy against colorectal cancer through inhibiting the STAT3 pathway

Colorectal cancer (CRC) accounts for about 10% of all annually diagnosed cancers and cancer‐related deaths worldwide. STAT3 plays a vital role in the occurrence and development of tumours. Gracillin has shown a significant antitumour activity in tumours, but its mechanism remains unknown. The human...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Lehe, Zhu, Tianru, Ye, Hua, Shen, Yili, Li, Zhiping, Chen, Luye, Wang, Canwei, Chen, Xia, Zhao, Haiyang, Xiang, Youqun, Xiao, Zhongxiang, Zhao, Chengguang, Li, Jifa, Hu, Wanle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812262/ https://www.ncbi.nlm.nih.gov/pubmed/33259114 http://dx.doi.org/10.1111/jcmm.16134

Ejemplares similares

Cynaropicrin Shows Antitumor Progression Potential in Colorectal Cancer Through Mediation of the LIFR/STATs Axis
por: Zheng, Dandan, et al.
Publicado: (2021)

L61H46 shows potent efficacy against human pancreatic cancer through inhibiting STAT3 pathway
por: Bai, Encheng, et al.
Publicado: (2018)

Rhein shows potent efficacy against non-small-cell lung cancer through inhibiting the STAT3 pathway
por: Yang, Lehe, et al.
Publicado: (2019)

Acetyl-bufalin shows potent efficacy against non-small-cell lung cancer by targeting the CDK9/STAT3 signalling pathway
por: Yang, Lehe, et al.
Publicado: (2020)

Rhein sensitizes human colorectal cancer cells to EGFR inhibitors by inhibiting STAT3 pathway
por: Zhuang, Yan, et al.
Publicado: (2019)

Rhein sensitizes human pancreatic cancer cells to EGFR inhibitors by inhibiting STAT3 pathway
por: Yang, Lehe, et al.
Publicado: (2019)

Flubendazole demonstrates valid antitumor effects by inhibiting STAT3 and activating autophagy
por: Lin, Shichong, et al.
Publicado: (2019)

The natural compound gracillin exerts potent antitumor activity by targeting mitochondrial complex II
por: Min, Hye-Young, et al.
Publicado: (2019)

Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer
por: Zhao, Zhucheng, et al.
Publicado: (2022)

Cinobufagin exerts an antitumor effect in non-small-cell lung cancer by blocking STAT3 signaling
por: Yan, Sunshun, et al.
Publicado: (2023)

Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer
por: Liu, Yanan, et al.
Publicado: (2021)

Potent Anticancer Effect of the Natural Steroidal Saponin Gracillin Is Produced by Inhibiting Glycolysis and Oxidative Phosphorylation-Mediated Bioenergetics
por: Min, Hye-Young, et al.
Publicado: (2020)

Nifuratel, a novel STAT3 inhibitor with potent activity against human gastric cancer cells
por: Zheng, Hailun, et al.
Publicado: (2017)

Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway
por: Li, Yamei, et al.
Publicado: (2022)

Acetyl-cinobufagin suppresses triple-negative breast cancer progression by inhibiting the STAT3 pathway
por: Qi, Yufeng, et al.
Publicado: (2023)

Design, Synthesis, And Evaluation Of Cyanopyridines As Anti-Colorectal Cancer Agents Via Inhibiting STAT3 Pathway
por: Xu, Lingyuan, et al.
Publicado: (2019)

Gracillin Isolated from Reineckia carnea Induces Apoptosis of A549 Cells via the Mitochondrial Pathway
por: Yang, Jianqiong, et al.
Publicado: (2021)

Twelve out of 117 recovered COVID-19 patients retest positive in a single-center study of China
por: Ye, Hua, et al.
Publicado: (2020)

Flubendazole Elicits Antitumor Effects by Inhibiting STAT3 and Activating Autophagy in Non-small Cell Lung Cancer
por: Xie, Xiaona, et al.
Publicado: (2021)

Niclosamide inhibition of STAT3 synergizes with erlotinib in human colon cancer
por: Shi, Lingyi, et al.
Publicado: (2017)

Osthole inhibits triple negative breast cancer cells by suppressing STAT3
por: Dai, Xuanxuan, et al.
Publicado: (2018)

Anti-Atopic Properties of Gracillin Isolated from Dioscorea quinqueloba on 2,4-Dinitrochlorobenzene-Induced Skin Lesions in Mice
por: Jegal, Jonghwan, et al.
Publicado: (2018)

Acid-responsive nanoparticles as a novel oxidative stress-inducing anticancer therapeutic agent for colon cancer
por: Zhao, Chengwei, et al.
Publicado: (2019)

Beneficial Effects of Gracillin From Rhizoma Paridis Against Gastric Carcinoma via the Potential TIPE2-Mediated Induction of Endogenous Apoptosis and Inhibition of Migration in BGC823 Cells
por: Liu, Wenming, et al.
Publicado: (2021)

Brevilin A exerts anti-colorectal cancer effects and potently inhibits STAT3 signaling invitro
por: Meng, Mingjing, et al.
Publicado: (2023)

The emerging role of the piRNA/PIWI complex in respiratory tract diseases
por: Yao, Yizhu, et al.
Publicado: (2023)

An Ethanolic Extract of Ampelopsis Radix Exerts Anti-colorectal Cancer Effects and Potently Inhibits STAT3 Signaling In Vitro
por: Su, Tao, et al.
Publicado: (2017)

Emerging Roles of Ubiquitin-Specific Protease 25 in Diseases
por: Zhu, Wenjing, et al.
Publicado: (2021)

Curcumin sensitizes human gastric cancer cells to 5-fluorouracil through inhibition of the NFκB survival-signaling pathway
por: Kang, Yanting, et al.
Publicado: (2016)

Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3
por: Wu, Song, et al.
Publicado: (2018)

Potent antitumor effects of cell-penetrating peptides targeting STAT3 axis
por: Aftabizadeh, Maryam, et al.
Publicado: (2021)

lncRNA MCF2L-AS1/miR-105/ IL-1β Axis Regulates Colorectal Cancer Cell Oxaliplatin Resistance
por: Cai, Mao, et al.
Publicado: (2021)

L61H46 Shows Potent Efficacy Against Human Pancreatic Cancer Through Inhibiting STAT3 Pathway [Erratum]
Publicado: (2019)

Propofol induces the ferroptosis of colorectal cancer cells by downregulating STAT3 expression
por: Zhao, Xining, et al.
Publicado: (2021)

AIM2 fosters lung adenocarcinoma immune escape by modulating PD-L1 expression in tumor-associated macrophages via JAK/STAT3
por: Ye, Hua, et al.
Publicado: (2023)

Icaritin Shows Potent Anti-Leukemia Activity on Chronic Myeloid Leukemia In Vitro and In Vivo by Regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT Signalings
por: Zhu, Jian feng, et al.
Publicado: (2011)

Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors
por: Brotherton-Pleiss, Christine, et al.
Publicado: (2020)

Comprehensive analysis of the prognostic and immunotherapeutic implications of STAT family members in human colorectal cancer
por: Li, Dingchang, et al.
Publicado: (2022)

Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells
por: Zhao, Chengguang, et al.
Publicado: (2015)

Neutralizing antibodies against EBV gp42 show potent in vivo protection and define novel epitopes
por: Wu, Qian, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j2lnir56ebqhtf58qajuaib3cq