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Neddylation inhibitor MLN4924 has anti‐HBV activity via modulating the ERK‐HNF1α‐C/EBPα‐HNF4α axis

Hepatitis B virus (HBV) infection is a major public health problem. The high levels of HBV DNA and HBsAg are positively associated with the development of secondary liver diseases, including hepatocellular carcinoma (HCC). Current treatment with nucleos(t)ide analogues mainly reduces viral DNA, but...

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Detalles Bibliográficos
Autores principales: Xie, Mingjie, Guo, Huiting, Lou, Guohua, Yao, Jiping, Liu, Yanning, Sun, Yi, Yang, Zhenggang, Zheng, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812279/
https://www.ncbi.nlm.nih.gov/pubmed/33263949
http://dx.doi.org/10.1111/jcmm.16137