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The protective effect of isosteviol sodium on cardiac function and myocardial remodelling in transverse aortic constriction rat
Pathological hypertrophy contributes to heart failure and there is not quite effective treatment to invert this process. Isosteviol has been shown to protect the heart against ischaemia‐reperfusion injury and isoproterenol‐induced cardiac hypertrophy, but its effect on pressure overload‐induced card...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812303/ https://www.ncbi.nlm.nih.gov/pubmed/33336505 http://dx.doi.org/10.1111/jcmm.16182 |
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author | Ke, Qingjin Liu, Fei Tang, Yuxin Chen, Jiedi Hu, Hui Sun, Xiaoou Tan, Wen |
author_facet | Ke, Qingjin Liu, Fei Tang, Yuxin Chen, Jiedi Hu, Hui Sun, Xiaoou Tan, Wen |
author_sort | Ke, Qingjin |
collection | PubMed |
description | Pathological hypertrophy contributes to heart failure and there is not quite effective treatment to invert this process. Isosteviol has been shown to protect the heart against ischaemia‐reperfusion injury and isoproterenol‐induced cardiac hypertrophy, but its effect on pressure overload‐induced cardiac hypertrophy is still unknown. Pressure overload induced by transverse aortic constriction (TAC) causes cardiac hypertrophy in rats to mimic the pathological condition in human. This study examined the effects of isosteviol sodium (STVNa) on cardiac hypertrophy by the TAC model and cellular assays in vitro. Cardiac function test, electrocardiogram analysis and histological analysis were conducted. The effects of STVNa on calcium transient of the adult rat ventricular cells and the proliferation of neonatal rat cardiac fibroblasts were also studied in vitro. Cardiac hypertrophy was observed after 3‐week TAC while the extensive cardiac dysfunction and electronic remodelling were observed after 9‐week TAC. Both STVNa and sildenafil (positive drug) treatment reversed the two process, but STVNa appeared to be more superior in some aspects and did not change calcium transient considerably. STVNa also reversed TAC‐induced cardiac fibrosis in vivo and TGF‐β1‐induced fibroblast proliferation in vitro. Moreover, STVNa, but not sildenafil, reversed impairment of the autonomic nervous system induced by 9‐week TAC. |
format | Online Article Text |
id | pubmed-7812303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78123032021-01-22 The protective effect of isosteviol sodium on cardiac function and myocardial remodelling in transverse aortic constriction rat Ke, Qingjin Liu, Fei Tang, Yuxin Chen, Jiedi Hu, Hui Sun, Xiaoou Tan, Wen J Cell Mol Med Original Articles Pathological hypertrophy contributes to heart failure and there is not quite effective treatment to invert this process. Isosteviol has been shown to protect the heart against ischaemia‐reperfusion injury and isoproterenol‐induced cardiac hypertrophy, but its effect on pressure overload‐induced cardiac hypertrophy is still unknown. Pressure overload induced by transverse aortic constriction (TAC) causes cardiac hypertrophy in rats to mimic the pathological condition in human. This study examined the effects of isosteviol sodium (STVNa) on cardiac hypertrophy by the TAC model and cellular assays in vitro. Cardiac function test, electrocardiogram analysis and histological analysis were conducted. The effects of STVNa on calcium transient of the adult rat ventricular cells and the proliferation of neonatal rat cardiac fibroblasts were also studied in vitro. Cardiac hypertrophy was observed after 3‐week TAC while the extensive cardiac dysfunction and electronic remodelling were observed after 9‐week TAC. Both STVNa and sildenafil (positive drug) treatment reversed the two process, but STVNa appeared to be more superior in some aspects and did not change calcium transient considerably. STVNa also reversed TAC‐induced cardiac fibrosis in vivo and TGF‐β1‐induced fibroblast proliferation in vitro. Moreover, STVNa, but not sildenafil, reversed impairment of the autonomic nervous system induced by 9‐week TAC. John Wiley and Sons Inc. 2020-12-17 2021-01 /pmc/articles/PMC7812303/ /pubmed/33336505 http://dx.doi.org/10.1111/jcmm.16182 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Ke, Qingjin Liu, Fei Tang, Yuxin Chen, Jiedi Hu, Hui Sun, Xiaoou Tan, Wen The protective effect of isosteviol sodium on cardiac function and myocardial remodelling in transverse aortic constriction rat |
title | The protective effect of isosteviol sodium on cardiac function and myocardial remodelling in transverse aortic constriction rat |
title_full | The protective effect of isosteviol sodium on cardiac function and myocardial remodelling in transverse aortic constriction rat |
title_fullStr | The protective effect of isosteviol sodium on cardiac function and myocardial remodelling in transverse aortic constriction rat |
title_full_unstemmed | The protective effect of isosteviol sodium on cardiac function and myocardial remodelling in transverse aortic constriction rat |
title_short | The protective effect of isosteviol sodium on cardiac function and myocardial remodelling in transverse aortic constriction rat |
title_sort | protective effect of isosteviol sodium on cardiac function and myocardial remodelling in transverse aortic constriction rat |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812303/ https://www.ncbi.nlm.nih.gov/pubmed/33336505 http://dx.doi.org/10.1111/jcmm.16182 |
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