Chronic vs acute manipulations reveal degeneracy in a thermosensory neuron network

Degenerate networks can drive similar circuit outputs. Via acute manipulation of individual neurons, we previously identified circuit components that are necessary and sufficient to drive starvation-dependent plasticity in C. elegans thermotaxis behavior. Here we find that when these components are...

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Detalles Bibliográficos
Autores principales: Yeon, Jihye, Takeishi, Asuka, Sengupta, Piali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2021
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812381/
https://www.ncbi.nlm.nih.gov/pubmed/33474527
http://dx.doi.org/10.17912/micropub.biology.000355
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author Yeon, Jihye
Takeishi, Asuka
Sengupta, Piali
author_facet Yeon, Jihye
Takeishi, Asuka
Sengupta, Piali
author_sort Yeon, Jihye
collection PubMed
description Degenerate networks can drive similar circuit outputs. Via acute manipulation of individual neurons, we previously identified circuit components that are necessary and sufficient to drive starvation-dependent plasticity in C. elegans thermotaxis behavior. Here we find that when these components are instead silenced chronically, degenerate mechanisms compensate to drive this behavior. Our results indicate that degeneracy in neuronal network function can be revealed under specific experimental conditions.
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spelling pubmed-78123812021-01-19 Chronic vs acute manipulations reveal degeneracy in a thermosensory neuron network Yeon, Jihye Takeishi, Asuka Sengupta, Piali MicroPubl Biol New Finding Degenerate networks can drive similar circuit outputs. Via acute manipulation of individual neurons, we previously identified circuit components that are necessary and sufficient to drive starvation-dependent plasticity in C. elegans thermotaxis behavior. Here we find that when these components are instead silenced chronically, degenerate mechanisms compensate to drive this behavior. Our results indicate that degeneracy in neuronal network function can be revealed under specific experimental conditions. Caltech Library 2021-01-15 /pmc/articles/PMC7812381/ /pubmed/33474527 http://dx.doi.org/10.17912/micropub.biology.000355 Text en Copyright: © 2021 by the authors https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Yeon, Jihye
Takeishi, Asuka
Sengupta, Piali
Chronic vs acute manipulations reveal degeneracy in a thermosensory neuron network
title Chronic vs acute manipulations reveal degeneracy in a thermosensory neuron network
title_full Chronic vs acute manipulations reveal degeneracy in a thermosensory neuron network
title_fullStr Chronic vs acute manipulations reveal degeneracy in a thermosensory neuron network
title_full_unstemmed Chronic vs acute manipulations reveal degeneracy in a thermosensory neuron network
title_short Chronic vs acute manipulations reveal degeneracy in a thermosensory neuron network
title_sort chronic vs acute manipulations reveal degeneracy in a thermosensory neuron network
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812381/
https://www.ncbi.nlm.nih.gov/pubmed/33474527
http://dx.doi.org/10.17912/micropub.biology.000355
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