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Endothelial Function in Patients With Von Willebrand Disease
In patients with von Willebrand disease (vWD) the interest in age-related comorbidities has grown, because the life expectancy of these patients has increased. The research question of this study was whether patients with vWD show a different endothelial function compared to the general population....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812404/ https://www.ncbi.nlm.nih.gov/pubmed/33448867 http://dx.doi.org/10.1177/1076029620984546 |
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author | Noone, Stephanie Schubert, Ralf Fichtlscherer, Stephan Hilberg, Thomas Alesci, Sonja Miesbach, Wolfgang |
author_facet | Noone, Stephanie Schubert, Ralf Fichtlscherer, Stephan Hilberg, Thomas Alesci, Sonja Miesbach, Wolfgang |
author_sort | Noone, Stephanie |
collection | PubMed |
description | In patients with von Willebrand disease (vWD) the interest in age-related comorbidities has grown, because the life expectancy of these patients has increased. The research question of this study was whether patients with vWD show a different endothelial function compared to the general population. A total of 37 patients with type 1 (n = 23), type 2 (n = 10) and type 3 (n = 4) vWD, 14 controls and 38 patients with coronary artery disease (CAD) were included in this study. Five markers of endothelial dysfunction (MOED) were determined. Moreover, the endothelial function was examined using the Itamar Endo-PAT. The reactive hyperemia index (RHI) was calculated from the results. The markers soluble intercellular adhesion molecule-1 (p = 0.171), P-Selectin (p = 0.512), interleukin-6 (p = 0.734) and monocyte chemoattractant protein-1 (p = 0.761) showed higher levels in patients with vWD, but were not significantly different compared to the control group. RHI was impaired in CAD-patients (1.855), whereas vWD patients had mean results of 1.870 and controls 2.112 (p = 0.367). In this study, the endothelial function measurements of patients with von Willebrand disease were not significantly different compared to healthy controls. |
format | Online Article Text |
id | pubmed-7812404 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-78124042021-01-26 Endothelial Function in Patients With Von Willebrand Disease Noone, Stephanie Schubert, Ralf Fichtlscherer, Stephan Hilberg, Thomas Alesci, Sonja Miesbach, Wolfgang Clin Appl Thromb Hemost Original Article In patients with von Willebrand disease (vWD) the interest in age-related comorbidities has grown, because the life expectancy of these patients has increased. The research question of this study was whether patients with vWD show a different endothelial function compared to the general population. A total of 37 patients with type 1 (n = 23), type 2 (n = 10) and type 3 (n = 4) vWD, 14 controls and 38 patients with coronary artery disease (CAD) were included in this study. Five markers of endothelial dysfunction (MOED) were determined. Moreover, the endothelial function was examined using the Itamar Endo-PAT. The reactive hyperemia index (RHI) was calculated from the results. The markers soluble intercellular adhesion molecule-1 (p = 0.171), P-Selectin (p = 0.512), interleukin-6 (p = 0.734) and monocyte chemoattractant protein-1 (p = 0.761) showed higher levels in patients with vWD, but were not significantly different compared to the control group. RHI was impaired in CAD-patients (1.855), whereas vWD patients had mean results of 1.870 and controls 2.112 (p = 0.367). In this study, the endothelial function measurements of patients with von Willebrand disease were not significantly different compared to healthy controls. SAGE Publications 2021-01-15 /pmc/articles/PMC7812404/ /pubmed/33448867 http://dx.doi.org/10.1177/1076029620984546 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Noone, Stephanie Schubert, Ralf Fichtlscherer, Stephan Hilberg, Thomas Alesci, Sonja Miesbach, Wolfgang Endothelial Function in Patients With Von Willebrand Disease |
title | Endothelial Function in Patients With Von Willebrand Disease |
title_full | Endothelial Function in Patients With Von Willebrand Disease |
title_fullStr | Endothelial Function in Patients With Von Willebrand Disease |
title_full_unstemmed | Endothelial Function in Patients With Von Willebrand Disease |
title_short | Endothelial Function in Patients With Von Willebrand Disease |
title_sort | endothelial function in patients with von willebrand disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812404/ https://www.ncbi.nlm.nih.gov/pubmed/33448867 http://dx.doi.org/10.1177/1076029620984546 |
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