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Molecular and epigenetic markers as promising tools to quantify the effect of occupational exposures and the risk of developing non-communicable diseases
Non-communicable diseases (NCDs) are chronic diseases that are by far the leading cause of death in the world. Many occupational hazards, together with social, economic and demographic factors, have been associated to NCDs development. Genetic susceptibility or environmental exposures alone are not...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Mattioli 1885 srl
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812541/ https://www.ncbi.nlm.nih.gov/pubmed/31268425 http://dx.doi.org/10.23749/mdl.v110i3.8538 |
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author | Ferrari, Luca Pavanello, Sofia Bollati, Valentina |
author_facet | Ferrari, Luca Pavanello, Sofia Bollati, Valentina |
author_sort | Ferrari, Luca |
collection | PubMed |
description | Non-communicable diseases (NCDs) are chronic diseases that are by far the leading cause of death in the world. Many occupational hazards, together with social, economic and demographic factors, have been associated to NCDs development. Genetic susceptibility or environmental exposures alone are not usually sufficient to explain the pathogenesis of NCDs, but can be integrated in a more complex scenario that can result in pathological phenotypes. Epigenetics is a crucial component of this scenario, as its changes are related to specific exposures, therefore potentially able to display the effects of environment on the genome, filling the gap between genetic asset and environment in explaining disease development. To date, the most promising biomarkers have been assessed in occupational cohorts as well as in case/control studies and include DNA methylation, histone modifications, microRNA expression, extracellular vesicles, telomere length, and mitochondrial alterations. |
format | Online Article Text |
id | pubmed-7812541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Mattioli 1885 srl |
record_format | MEDLINE/PubMed |
spelling | pubmed-78125412021-01-29 Molecular and epigenetic markers as promising tools to quantify the effect of occupational exposures and the risk of developing non-communicable diseases Ferrari, Luca Pavanello, Sofia Bollati, Valentina Med Lav Original Article Non-communicable diseases (NCDs) are chronic diseases that are by far the leading cause of death in the world. Many occupational hazards, together with social, economic and demographic factors, have been associated to NCDs development. Genetic susceptibility or environmental exposures alone are not usually sufficient to explain the pathogenesis of NCDs, but can be integrated in a more complex scenario that can result in pathological phenotypes. Epigenetics is a crucial component of this scenario, as its changes are related to specific exposures, therefore potentially able to display the effects of environment on the genome, filling the gap between genetic asset and environment in explaining disease development. To date, the most promising biomarkers have been assessed in occupational cohorts as well as in case/control studies and include DNA methylation, histone modifications, microRNA expression, extracellular vesicles, telomere length, and mitochondrial alterations. Mattioli 1885 srl 2019 2019-06-28 /pmc/articles/PMC7812541/ /pubmed/31268425 http://dx.doi.org/10.23749/mdl.v110i3.8538 Text en Copyright: © 2020 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Original Article Ferrari, Luca Pavanello, Sofia Bollati, Valentina Molecular and epigenetic markers as promising tools to quantify the effect of occupational exposures and the risk of developing non-communicable diseases |
title | Molecular and epigenetic markers as promising tools to quantify the effect of occupational exposures and the risk of developing non-communicable diseases |
title_full | Molecular and epigenetic markers as promising tools to quantify the effect of occupational exposures and the risk of developing non-communicable diseases |
title_fullStr | Molecular and epigenetic markers as promising tools to quantify the effect of occupational exposures and the risk of developing non-communicable diseases |
title_full_unstemmed | Molecular and epigenetic markers as promising tools to quantify the effect of occupational exposures and the risk of developing non-communicable diseases |
title_short | Molecular and epigenetic markers as promising tools to quantify the effect of occupational exposures and the risk of developing non-communicable diseases |
title_sort | molecular and epigenetic markers as promising tools to quantify the effect of occupational exposures and the risk of developing non-communicable diseases |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812541/ https://www.ncbi.nlm.nih.gov/pubmed/31268425 http://dx.doi.org/10.23749/mdl.v110i3.8538 |
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