The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity

BACKGROUND: The IκB kinase (IKK) complex, comprising the two enzymes IKKα and IKKβ, is the main activator of the inflammatory transcription factor NF-κB, which is constitutively active in many cancers. While several connections between NF-κB signaling and the oncogene c-Myc have been shown, function...

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Detalles Bibliográficos
Autores principales: Moser, Bernhard, Hochreiter, Bernhard, Basílio, José, Gleitsmann, Viola, Panhuber, Anja, Pardo-Garcia, Alan, Hoesel, Bastian, Salzmann, Manuel, Resch, Ulrike, Noreen, Mamoona, Schmid, Johannes A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812655/
https://www.ncbi.nlm.nih.gov/pubmed/33461590
http://dx.doi.org/10.1186/s12943-021-01308-8

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