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The role of m(6)A, m(5)C and Ψ RNA modifications in cancer: Novel therapeutic opportunities

RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programmes. Significant advances have been made in understanding the functional role of RNA modifications in regulating coding and non-coding RNA processing and function, which in turn thoroughly sh...

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Autores principales: Nombela, Paz, Miguel-López, Borja, Blanco, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812662/
https://www.ncbi.nlm.nih.gov/pubmed/33461542
http://dx.doi.org/10.1186/s12943-020-01263-w
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author Nombela, Paz
Miguel-López, Borja
Blanco, Sandra
author_facet Nombela, Paz
Miguel-López, Borja
Blanco, Sandra
author_sort Nombela, Paz
collection PubMed
description RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programmes. Significant advances have been made in understanding the functional role of RNA modifications in regulating coding and non-coding RNA processing and function, which in turn thoroughly shape distinct gene expression programmes. They affect diverse biological processes, and the correct deposition of many of these modifications is required for normal development. Alterations of their deposition are implicated in several diseases, including cancer. In this Review, we focus on the occurrence of N(6)-methyladenosine (m(6)A), 5-methylcytosine (m(5)C) and pseudouridine (Ψ) in coding and non-coding RNAs and describe their physiopathological role in cancer. We will highlight the latest insights into the mechanisms of how these posttranscriptional modifications influence tumour development, maintenance, and progression. Finally, we will summarize the latest advances on the development of small molecule inhibitors that target specific writers or erasers to rewind the epitranscriptome of a cancer cell and their therapeutic potential.
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spelling pubmed-78126622021-01-19 The role of m(6)A, m(5)C and Ψ RNA modifications in cancer: Novel therapeutic opportunities Nombela, Paz Miguel-López, Borja Blanco, Sandra Mol Cancer Review RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programmes. Significant advances have been made in understanding the functional role of RNA modifications in regulating coding and non-coding RNA processing and function, which in turn thoroughly shape distinct gene expression programmes. They affect diverse biological processes, and the correct deposition of many of these modifications is required for normal development. Alterations of their deposition are implicated in several diseases, including cancer. In this Review, we focus on the occurrence of N(6)-methyladenosine (m(6)A), 5-methylcytosine (m(5)C) and pseudouridine (Ψ) in coding and non-coding RNAs and describe their physiopathological role in cancer. We will highlight the latest insights into the mechanisms of how these posttranscriptional modifications influence tumour development, maintenance, and progression. Finally, we will summarize the latest advances on the development of small molecule inhibitors that target specific writers or erasers to rewind the epitranscriptome of a cancer cell and their therapeutic potential. BioMed Central 2021-01-18 /pmc/articles/PMC7812662/ /pubmed/33461542 http://dx.doi.org/10.1186/s12943-020-01263-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Nombela, Paz
Miguel-López, Borja
Blanco, Sandra
The role of m(6)A, m(5)C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
title The role of m(6)A, m(5)C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
title_full The role of m(6)A, m(5)C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
title_fullStr The role of m(6)A, m(5)C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
title_full_unstemmed The role of m(6)A, m(5)C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
title_short The role of m(6)A, m(5)C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
title_sort role of m(6)a, m(5)c and ψ rna modifications in cancer: novel therapeutic opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812662/
https://www.ncbi.nlm.nih.gov/pubmed/33461542
http://dx.doi.org/10.1186/s12943-020-01263-w
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