Solution Conformations Shed Light on PROTAC Cell Permeability

[Image: see text] Proteolysis targeting chimeras (PROTACs) induce intracellular degradation of target proteins. Their bifunctional structure puts degraders in a chemical space where ADME properties often complicate drug discovery. Herein we provide the first structural insight into PROTAC cell perme...

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Detalles Bibliográficos
Autores principales: Atilaw, Yoseph, Poongavanam, Vasanthanathan, Svensson Nilsson, Caroline, Nguyen, Duy, Giese, Anja, Meibom, Daniel, Erdelyi, Mate, Kihlberg, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812666/
https://www.ncbi.nlm.nih.gov/pubmed/33488971
http://dx.doi.org/10.1021/acsmedchemlett.0c00556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812666/
https://www.ncbi.nlm.nih.gov/pubmed/33488971
http://dx.doi.org/10.1021/acsmedchemlett.0c00556

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