Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma

BACKGROUND: Despite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent®), or by combinations of anti-angiogenic drugs with immunotherapy, metastatic clear cell Renal Cell Carcinoma (mccRCC) remain incurable. Hence, new relevant treatments are urgently n...

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Detalles Bibliográficos
Autores principales: Dumond, Aurore, Brachet, Etienne, Durivault, Jérôme, Vial, Valérie, Puszko, Anna K., Lepelletier, Yves, Montemagno, Christopher, Pagnuzzi-Boncompagni, Marina, Hermine, Olivier, Garbay, Christiane, Lagarde, Nathalie, Montes, Matthieu, Demange, Luc, Grépin, Renaud, Pagès, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812727/
https://www.ncbi.nlm.nih.gov/pubmed/33461580
http://dx.doi.org/10.1186/s13046-021-01832-x

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