Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors

Thrombopoietin (TPO) and the TPO-receptor (TPO-R, or c-MPL) are essential for hematopoietic stem cell (HSC) maintenance and megakaryocyte differentiation. Agents that can modulate TPO-R signaling are highly desirable for both basic research and clinical utility. We developed a series of surrogate pr...

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Detalles Bibliográficos
Autores principales: Cui, Lu, Moraga, Ignacio, Lerbs, Tristan, Van Neste, Camille, Wilmes, Stephan, Tsutsumi, Naotaka, Trotman-Grant, Aaron Claudius, Gakovic, Milica, Andrews, Sarah, Gotlib, Jason, Darmanis, Spyros, Enge, Martin, Quake, Stephen, Hitchcock, Ian S., Piehler, Jacob, Garcia, K. Christopher, Wernig, Gerlinde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812794/
https://www.ncbi.nlm.nih.gov/pubmed/33384332
http://dx.doi.org/10.1073/pnas.2017849118

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