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Knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs

The sex-determining region on the Y chromosome (SRY) is thought to be the central genetic element of male sex development in mammals. Pathogenic modifications within the SRY gene are associated with a male-to-female sex reversal syndrome in humans and other mammalian species, including rabbits and m...

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Detalles Bibliográficos
Autores principales:	Kurtz, Stefanie, Lucas-Hahn, Andrea, Schlegelberger, Brigitte, Göhring, Gudrun, Niemann, Heiner, Mettenleiter, Thomas C., Petersen, Björn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812820/ https://www.ncbi.nlm.nih.gov/pubmed/33443157 http://dx.doi.org/10.1073/pnas.2008743118

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