siRNA potency enhancement via chemical modifications of nucleotide bases at the 5′-end of the siRNA guide strand

Small interfering RNAs (siRNAs) can be utilized not only as functional biological research tools but also as therapeutic agents. For the clinical use of siRNA as drugs, various chemical modifications have been used to improve the activity of siRNA drugs, and further chemical modifications are expect...

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Detalles Bibliográficos
Autores principales: Shinohara, Fumikazu, Oashi, Taiji, Harumoto, Toshimasa, Nishikawa, Tomoyuki, Takayama, Yuki, Miyagi, Hikaru, Takahashi, Yuichi, Nakajima, Takahiro, Sawada, Takashi, Koda, Yasuo, Makino, Asana, Sato, Atsuko, Hamaguchi, Kaori, Suzuki, Michihiko, Yamamoto, Junichiro, Tomari, Yukihide, Saito, Jun-Ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812868/
https://www.ncbi.nlm.nih.gov/pubmed/33177188
http://dx.doi.org/10.1261/rna.073783.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812868/
https://www.ncbi.nlm.nih.gov/pubmed/33177188
http://dx.doi.org/10.1261/rna.073783.119

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