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Effect of a fever in viral infections — the ‘Goldilocks’ phenomenon?

Acute infections, including those due to Coronaviridae and other viruses, often stimulate a febrile response. A mild fever appears to improve outcome; it appears to diminish viral replication by several mechanisms, including virion entry into host cells and genome transcription, and improving host d...

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Autores principales: Belon, Lucas, Skidmore, Peter, Mehra, Rohan, Walter, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812885/
https://www.ncbi.nlm.nih.gov/pubmed/33521098
http://dx.doi.org/10.12998/wjcc.v9.i2.296
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author Belon, Lucas
Skidmore, Peter
Mehra, Rohan
Walter, Edward
author_facet Belon, Lucas
Skidmore, Peter
Mehra, Rohan
Walter, Edward
author_sort Belon, Lucas
collection PubMed
description Acute infections, including those due to Coronaviridae and other viruses, often stimulate a febrile response. A mild fever appears to improve outcome; it appears to diminish viral replication by several mechanisms, including virion entry into host cells and genome transcription, and improving host defence mechanisms against the pathogen. However, a fever may also damage host cellular and tissue function and increase metabolic demands. At temperatures at the lower end of the febrile range, the benefit of the fever appears to outweigh the detrimental effects. However, at higher temperatures, the outcome worsens, suggesting that the disadvantages of fever on the host predominate. A non-infective fever is associated with a worse outcome at lower temperatures, suggesting that hyperthermia carries less benefit in the absence of infection. This review discusses the risks and benefits of a fever on the host response, focusing on the effects of a fever on viral replication and host response, and the detrimental effect on the host.
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spelling pubmed-78128852021-01-28 Effect of a fever in viral infections — the ‘Goldilocks’ phenomenon? Belon, Lucas Skidmore, Peter Mehra, Rohan Walter, Edward World J Clin Cases Review Acute infections, including those due to Coronaviridae and other viruses, often stimulate a febrile response. A mild fever appears to improve outcome; it appears to diminish viral replication by several mechanisms, including virion entry into host cells and genome transcription, and improving host defence mechanisms against the pathogen. However, a fever may also damage host cellular and tissue function and increase metabolic demands. At temperatures at the lower end of the febrile range, the benefit of the fever appears to outweigh the detrimental effects. However, at higher temperatures, the outcome worsens, suggesting that the disadvantages of fever on the host predominate. A non-infective fever is associated with a worse outcome at lower temperatures, suggesting that hyperthermia carries less benefit in the absence of infection. This review discusses the risks and benefits of a fever on the host response, focusing on the effects of a fever on viral replication and host response, and the detrimental effect on the host. Baishideng Publishing Group Inc 2021-01-16 2021-01-16 /pmc/articles/PMC7812885/ /pubmed/33521098 http://dx.doi.org/10.12998/wjcc.v9.i2.296 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Review
Belon, Lucas
Skidmore, Peter
Mehra, Rohan
Walter, Edward
Effect of a fever in viral infections — the ‘Goldilocks’ phenomenon?
title Effect of a fever in viral infections — the ‘Goldilocks’ phenomenon?
title_full Effect of a fever in viral infections — the ‘Goldilocks’ phenomenon?
title_fullStr Effect of a fever in viral infections — the ‘Goldilocks’ phenomenon?
title_full_unstemmed Effect of a fever in viral infections — the ‘Goldilocks’ phenomenon?
title_short Effect of a fever in viral infections — the ‘Goldilocks’ phenomenon?
title_sort effect of a fever in viral infections — the ‘goldilocks’ phenomenon?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812885/
https://www.ncbi.nlm.nih.gov/pubmed/33521098
http://dx.doi.org/10.12998/wjcc.v9.i2.296
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