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HMGB1, the Next Predictor of Transcatheter Arterial Chemoembolization for Liver Metastasis of Colorectal Cancer?
HMGB1 is an important mediator of inflammation during ischemia–reperfusion injury on organs. The serum expression of HMGB1 was increased significantly on the 1st day after TACE and decreased significantly which was lower on the 30th day after TACE. Tumor markers of post-DEB-TACE decreased significan...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812918/ https://www.ncbi.nlm.nih.gov/pubmed/33473353 http://dx.doi.org/10.3389/fonc.2020.572418 |
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author | Sun, Yuan-dong Zhang, Hao Chen, Ye-qiang Wu, Chun-xue Zhang, Jian-bo Xu, Hui-rong Liu, Jing-zhou Han, Jian-jun |
author_facet | Sun, Yuan-dong Zhang, Hao Chen, Ye-qiang Wu, Chun-xue Zhang, Jian-bo Xu, Hui-rong Liu, Jing-zhou Han, Jian-jun |
author_sort | Sun, Yuan-dong |
collection | PubMed |
description | HMGB1 is an important mediator of inflammation during ischemia–reperfusion injury on organs. The serum expression of HMGB1 was increased significantly on the 1st day after TACE and decreased significantly which was lower on the 30th day after TACE. Tumor markers of post-DEB-TACE decreased significantly. The correlational analysis showed that patients with low HMGB1 expression had lower risks of fever and liver injury compared those with the higher expression, while the ORR is relatively worse. Patients with lower expression of HMGB1 had longer PFS, better efficacy, and higher quality of life. With the high post-expression, the low expression had lower incidence of fever and liver injury too. There was no statistical difference in the one-year survival among the different groups. The quality of life of all patients was improved significantly. The over-expression of HMGB1 in LMCRC is an adverse prognostic feature and a positive predictor of response to TACE. |
format | Online Article Text |
id | pubmed-7812918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78129182021-01-19 HMGB1, the Next Predictor of Transcatheter Arterial Chemoembolization for Liver Metastasis of Colorectal Cancer? Sun, Yuan-dong Zhang, Hao Chen, Ye-qiang Wu, Chun-xue Zhang, Jian-bo Xu, Hui-rong Liu, Jing-zhou Han, Jian-jun Front Oncol Oncology HMGB1 is an important mediator of inflammation during ischemia–reperfusion injury on organs. The serum expression of HMGB1 was increased significantly on the 1st day after TACE and decreased significantly which was lower on the 30th day after TACE. Tumor markers of post-DEB-TACE decreased significantly. The correlational analysis showed that patients with low HMGB1 expression had lower risks of fever and liver injury compared those with the higher expression, while the ORR is relatively worse. Patients with lower expression of HMGB1 had longer PFS, better efficacy, and higher quality of life. With the high post-expression, the low expression had lower incidence of fever and liver injury too. There was no statistical difference in the one-year survival among the different groups. The quality of life of all patients was improved significantly. The over-expression of HMGB1 in LMCRC is an adverse prognostic feature and a positive predictor of response to TACE. Frontiers Media S.A. 2020-12-15 /pmc/articles/PMC7812918/ /pubmed/33473353 http://dx.doi.org/10.3389/fonc.2020.572418 Text en Copyright © 2020 Sun, Zhang, Chen, Wu, Zhang, Xu, Liu and Han http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Sun, Yuan-dong Zhang, Hao Chen, Ye-qiang Wu, Chun-xue Zhang, Jian-bo Xu, Hui-rong Liu, Jing-zhou Han, Jian-jun HMGB1, the Next Predictor of Transcatheter Arterial Chemoembolization for Liver Metastasis of Colorectal Cancer? |
title | HMGB1, the Next Predictor of Transcatheter Arterial Chemoembolization for Liver Metastasis of Colorectal Cancer? |
title_full | HMGB1, the Next Predictor of Transcatheter Arterial Chemoembolization for Liver Metastasis of Colorectal Cancer? |
title_fullStr | HMGB1, the Next Predictor of Transcatheter Arterial Chemoembolization for Liver Metastasis of Colorectal Cancer? |
title_full_unstemmed | HMGB1, the Next Predictor of Transcatheter Arterial Chemoembolization for Liver Metastasis of Colorectal Cancer? |
title_short | HMGB1, the Next Predictor of Transcatheter Arterial Chemoembolization for Liver Metastasis of Colorectal Cancer? |
title_sort | hmgb1, the next predictor of transcatheter arterial chemoembolization for liver metastasis of colorectal cancer? |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812918/ https://www.ncbi.nlm.nih.gov/pubmed/33473353 http://dx.doi.org/10.3389/fonc.2020.572418 |
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