Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and aggressive form of ovarian cancer. SCCOHT tumors have inactivating mutations in SMARCA4 (BRG1), one of the two mutually exclusive ATPases of the SWI/SNF chromatin remodeling complex. To address the role that BRG1 loss plays...

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Detalles Bibliográficos
Autores principales: Orlando, Krystal Ann, Douglas, Amber K, Abudu, Aierken, Wang, Yemin, Tessier-Cloutier, Basile, Su, Weiping, Peters, Alec, Sherman, Larry S, Moore, Rayvon, Nguyen, Vinh, Negri, Gian Luca, Colborne, Shane, Morin, Gregg B, Kommoss, Friedrich, Lang, Jessica D, Hendricks, William PD, Raupach, Elizabeth A, Pirrotte, Patrick, Huntsman, David G, Trent, Jeffrey M, Parker, Joel S, Raab, Jesse R, Weissman, Bernard E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813545/
https://www.ncbi.nlm.nih.gov/pubmed/33355532
http://dx.doi.org/10.7554/eLife.59073

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