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Dilatations des bronches chez les patients porteurs de bronchopneumopathie chronique obstructive au centre Tunisien: impact sur l’évolution et le pronostic
INTRODUCTION: bronchial dilations (BDs) seem to have a major role in the natural history of chronic obstructive pulmonary disease (COPD). The purpose of our study was to evaluate the impact of BDs on the severity and progression of COPD as well as on patients’ prognosis. METHODS: we conducted a retr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The African Field Epidemiology Network
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813652/ https://www.ncbi.nlm.nih.gov/pubmed/33505569 http://dx.doi.org/10.11604/pamj.2020.37.200.24448 |
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author | Saad, Ahmed Ben Migaou, Asma Mhamed, Saousen Cheikh Fahem, Nesrine Rouatbi, Naceur Joobeur, Samah |
author_facet | Saad, Ahmed Ben Migaou, Asma Mhamed, Saousen Cheikh Fahem, Nesrine Rouatbi, Naceur Joobeur, Samah |
author_sort | Saad, Ahmed Ben |
collection | PubMed |
description | INTRODUCTION: bronchial dilations (BDs) seem to have a major role in the natural history of chronic obstructive pulmonary disease (COPD). The purpose of our study was to evaluate the impact of BDs on the severity and progression of COPD as well as on patients’ prognosis. METHODS: we conducted a retrospective, single-center, analytical study over the period 1995- 2017. The study was based on data from the medical records of patients with COPD who had undergone chest CT scan during the follow-up period. We compared two groups (G) of patients: G1: COPD with BDs; G2: COPD without BDs. RESULTS: our study included 466 patients with COPD. Among them 101 (21.6%) had BDs associated with COPD. G1 patients had lower maximum expiratory volume in the first second (FEV1) (G1: 1.21 L, G2: 1.37 L, p = 0.015), lower forced vital capacity (FVC) (p = 0.014), a lower PaO2 at steady state (p = 0.049), a higher rate of acute exacerbations (AE) per year (G1: 3.31, G2: 2.44, p = 0.001) and a higher rate of hospitalizations in the Intensive Care Unit per year (p = 0.02). G1 patients with AE receiving treatment in hospital had lower PaO2 3) on admission (G1: 60 mmHg, G2: 63.7 mmHg, p = 0.02 G2: 63.7 mmHg, p = 0.023), more elevated carbon dioxide (CO2) levels (p = 0.001) and were characterized by a higher use of non-invasive ventilation (NIV) (p = 0.044) and invasive mechanical ventilation (p = 0.011). G2 patients had better overall survival (p = 0.002). CONCLUSION: bronchial dilatations are an indicator of poor prognosis in patients with chronic obstructive pulmonary disease, expecially because of the higher rate and severity of exacerbations, airway obstructions and mortality. |
format | Online Article Text |
id | pubmed-7813652 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The African Field Epidemiology Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-78136522021-01-26 Dilatations des bronches chez les patients porteurs de bronchopneumopathie chronique obstructive au centre Tunisien: impact sur l’évolution et le pronostic Saad, Ahmed Ben Migaou, Asma Mhamed, Saousen Cheikh Fahem, Nesrine Rouatbi, Naceur Joobeur, Samah Pan Afr Med J Research INTRODUCTION: bronchial dilations (BDs) seem to have a major role in the natural history of chronic obstructive pulmonary disease (COPD). The purpose of our study was to evaluate the impact of BDs on the severity and progression of COPD as well as on patients’ prognosis. METHODS: we conducted a retrospective, single-center, analytical study over the period 1995- 2017. The study was based on data from the medical records of patients with COPD who had undergone chest CT scan during the follow-up period. We compared two groups (G) of patients: G1: COPD with BDs; G2: COPD without BDs. RESULTS: our study included 466 patients with COPD. Among them 101 (21.6%) had BDs associated with COPD. G1 patients had lower maximum expiratory volume in the first second (FEV1) (G1: 1.21 L, G2: 1.37 L, p = 0.015), lower forced vital capacity (FVC) (p = 0.014), a lower PaO2 at steady state (p = 0.049), a higher rate of acute exacerbations (AE) per year (G1: 3.31, G2: 2.44, p = 0.001) and a higher rate of hospitalizations in the Intensive Care Unit per year (p = 0.02). G1 patients with AE receiving treatment in hospital had lower PaO2 3) on admission (G1: 60 mmHg, G2: 63.7 mmHg, p = 0.02 G2: 63.7 mmHg, p = 0.023), more elevated carbon dioxide (CO2) levels (p = 0.001) and were characterized by a higher use of non-invasive ventilation (NIV) (p = 0.044) and invasive mechanical ventilation (p = 0.011). G2 patients had better overall survival (p = 0.002). CONCLUSION: bronchial dilatations are an indicator of poor prognosis in patients with chronic obstructive pulmonary disease, expecially because of the higher rate and severity of exacerbations, airway obstructions and mortality. The African Field Epidemiology Network 2020-10-29 /pmc/articles/PMC7813652/ /pubmed/33505569 http://dx.doi.org/10.11604/pamj.2020.37.200.24448 Text en Copyright: Ahmed Ben Saad et al. https://creativecommons.org/licenses/by/4.0 The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Saad, Ahmed Ben Migaou, Asma Mhamed, Saousen Cheikh Fahem, Nesrine Rouatbi, Naceur Joobeur, Samah Dilatations des bronches chez les patients porteurs de bronchopneumopathie chronique obstructive au centre Tunisien: impact sur l’évolution et le pronostic |
title | Dilatations des bronches chez les patients porteurs de bronchopneumopathie chronique obstructive au centre Tunisien: impact sur l’évolution et le pronostic |
title_full | Dilatations des bronches chez les patients porteurs de bronchopneumopathie chronique obstructive au centre Tunisien: impact sur l’évolution et le pronostic |
title_fullStr | Dilatations des bronches chez les patients porteurs de bronchopneumopathie chronique obstructive au centre Tunisien: impact sur l’évolution et le pronostic |
title_full_unstemmed | Dilatations des bronches chez les patients porteurs de bronchopneumopathie chronique obstructive au centre Tunisien: impact sur l’évolution et le pronostic |
title_short | Dilatations des bronches chez les patients porteurs de bronchopneumopathie chronique obstructive au centre Tunisien: impact sur l’évolution et le pronostic |
title_sort | dilatations des bronches chez les patients porteurs de bronchopneumopathie chronique obstructive au centre tunisien: impact sur l’évolution et le pronostic |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813652/ https://www.ncbi.nlm.nih.gov/pubmed/33505569 http://dx.doi.org/10.11604/pamj.2020.37.200.24448 |
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